Hedjoudje Abdellah, Cheurfa Chérifa, Briquez Clément, Zhang Allen, Koch Stéphane, Vuitton Lucine
Gastro-entérologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon (Abdellah Hedjoudje, Clément Briquez, Stéphane Koch, Lucine Vuitton); Faculté de Médecine, Université Paris Descartes, Paris (Chérifa Cheurfa).
Faculté de Médecine, Université Paris Descartes, Paris (Chérifa Cheurfa); Anésthésie réanimation, CHU Charles Nicolle, Rouen, France (Chérifa Cheurfa).
Ann Gastroenterol. 2017;30(2):197-208. doi: 10.20524/aog.2017.0121. Epub 2017 Jan 5.
Although the rs2476601 polymorphism of has been reported to be a susceptibility gene for Crohn's disease (CD), results from different studies vary and remain inconclusive. Also, no association has been found between rs2476601 and the risk of ulcerative colitis (UC). The aim of this meta-analysis was to investigate the association between this polymorphism (rs2476601) and the risk of inflammatory bowel disease, UC and CD.
We performed a meta-analysis by identifying relevant candidate gene-based studies from EMBASE and MEDLINE. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate the strength of associations between rs2476601 and inflammatory bowel diseases, using a fixed effect or random effect model. Publication bias was also assessed.
By pooling 14 different studies, 13,356 controls, 8182 patients with CD, and 8656 with UC were included. We found that the T allele of was not significantly associated with a higher risk of developing UC (OR 1.06, 95%CI 0.98-1.14) but was associated with a decreased risk of developing CD (OR 1.28, 95%CI 1.17-1.40). The T allele in rs2476601 lowered the risk of CD by 22%.
This study shows that (rs2476601) is significantly associated with the risk of developing CD, but has no association with UC. This suggests that these diseases have different pathways involved in their pathophysiology.
尽管已有报道称[基因名称]的rs2476601多态性是克罗恩病（CD）的易感基因，但不同研究的结果各异且尚无定论。此外，未发现rs2476601与溃疡性结肠炎（UC）风险之间存在关联。本荟萃分析的目的是研究该[基因名称]多态性（rs2476601）与炎症性肠病、UC和CD风险之间的关联。
我们通过从EMBASE和MEDLINE中识别相关的基于候选基因的研究来进行荟萃分析。计算比值比（OR）和95%置信区间（CI），以使用固定效应或随机效应模型估计rs2476601与炎症性肠病之间关联的强度。还评估了发表偏倚。
汇总14项不同研究后，纳入了13356名对照、8182例CD患者和8656例UC患者。我们发现[基因名称]的T等位基因与UC发病风险升高无显著关联（OR 1.06，95%CI 0.98 - 1.14），但与CD发病风险降低有关（OR 1.28，95%CI 1.17 - 1.40）。rs2476601中的T等位基因使CD风险降低了22%。
本研究表明[基因名称]（rs2476601）与CD发病风险显著相关，但与UC无关。这表明这些疾病在其病理生理学中涉及不同的途径。
