Yang Xiangyun, Luo Jia, Zhong Zhaoxi, Yang Xiaojie, Yao Shumin, Wang Pengchong, Gao Jian, Liu Rui, Sun Jing, Li Zhanjiang
The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Front Psychiatry. 2019 Jun 28;10:452. doi: 10.3389/fpsyt.2019.00452. eCollection 2019.
Previous studies suggest that abnormal brain structure and function may be neuroimaging endophenotypes of obsessive-compulsive disorder (OCD). Comparing the intrinsic brain activity of OCD patients and their unaffected siblings will help to further understand the susceptibility to, and pathological mechanisms of, OCD. We used a case-control study design aiming to establish whether the abnormal regional homogeneity (ReHo) found in OCD patients also exists in their unaffected siblings. Fifteen unmedicated OCD patients, 15 of their unaffected siblings, and 30 healthy controls (HCs) received resting-state functional magnetic resonance imaging (r-s fMRI) scanning and clinical evaluation. We used the ReHo method to analyze the inter-regional synchronized activity of all participants. One-way analysis of covariance with post hoc tests was used to compare the ReHo maps across groups. A Pearson correlation analysis was conducted to assess the correlations between clinical characteristics and abnormal ReHo in OCD patients. Relative to HCs, OCD patients and their unaffected siblings showed overlapping higher ReHo values in the right dorsolateral prefrontal cortex (DLPFC). Patients with OCD showed increased ReHo in left middle frontal gyrus (MFG) relative to both their unaffected siblings and HCs. In addition to the right DLPFC and left MFG, OCD patients, compared with HCs, also showed abnormal ReHo in other regions, including higher ReHo in the right superior parietal cortex and lower ReHo in the left inferior parietal cortex, right parahippocampal region, left thalamus, and right inferior temporal cortex. Compared with HCs, the unaffected siblings of patients with OCD had significantly higher ReHo in the right inferior parietal cortex, right MFG, and right supplementary motor area. There was no association between clinical symptoms and abnormal ReHo values in OCD patients. This study found overlapping higher ReHo values in the right DLPFC of OCD patients and their unaffected siblings. Our results suggest that the higher ReHo in the right DLPFC may be a potential neuroimaging endophenotype, which may reflect an increased genetic risk of OCD.
以往研究表明，大脑结构和功能异常可能是强迫症（OCD）的神经影像学内表型。比较强迫症患者及其未患病同胞的大脑内在活动，将有助于进一步了解强迫症的易感性和病理机制。我们采用病例对照研究设计，旨在确定在强迫症患者中发现的异常局部一致性（ReHo）是否也存在于其未患病同胞中。15名未接受药物治疗的强迫症患者、15名其未患病同胞以及30名健康对照者（HCs）接受了静息态功能磁共振成像（r-s fMRI）扫描和临床评估。我们使用ReHo方法分析所有参与者的区域间同步活动。采用协方差分析及事后检验对各组的ReHo图谱进行比较。进行Pearson相关分析以评估强迫症患者临床特征与异常ReHo之间的相关性。相对于HCs，强迫症患者及其未患病同胞在右侧背外侧前额叶皮质（DLPFC）表现出重叠的较高ReHo值。与未患病同胞和HCs相比，强迫症患者在左侧额中回（MFG）的ReHo增加。除了右侧DLPFC和左侧MFG外，与HCs相比，强迫症患者在其他区域也表现出异常ReHo，包括右侧顶上叶皮质ReHo较高，左侧顶下叶皮质、右侧海马旁区域、左侧丘脑和右侧颞下叶皮质ReHo较低。与HCs相比，强迫症患者的未患病同胞在右侧顶下叶皮质、右侧MFG和右侧辅助运动区的ReHo显著更高。强迫症患者的临床症状与异常ReHo值之间无关联。本研究发现强迫症患者及其未患病同胞在右侧DLPFC存在重叠的较高ReHo值。我们的结果表明，右侧DLPFC中较高的ReHo可能是一种潜在的神经影像学内表型，可能反映了强迫症增加的遗传风险。
