Ro J Y, Silva E G, Gallager H S
Department of Pathology, University of Texas M.D. Anderson Hospital and Tumor Insititute, Houston 77030.
Hum Pathol. 1987 Dec;18(12):1276-81. doi: 10.1016/s0046-8177(87)80413-6.
Twelve cases of pure adenoid cystic carcinoma of the breast were reviewed. Patients ranged in age from 34 to 69 years. Seven carcinomas were in the right breast, and five in the left; five of the 12 were located in the central region of the breast, five in the upper outer quadrant, and the two in the upper inner and lower inner quadrants, respectively. Average diameter of the primary tumors was 2.5 cm (range, 0.7 to 6.0). We graded the tumors according to a system used for adenoid cystic carcinoma of the salivary gland: five tumors were grade I, six were grade II, and one was grade III. An average of 5 years after diagnosis, all patients with grade I tumors were either alive without evidence of disease or had died of unrelated causes. Among the six patients with grade II tumors, one developed a local recurrence 5 years after diagnosis and subsequent pulmonary metastasis, and one died of metastatic adenoid cystic carcinoma 13 years after diagnosis. The one patient with grade III tumor had shown metastases in axillary lymph nodes at mastectomy, and she died of disease 2 years later. These findings suggest that the grading of adenoid cystic carcinoma of the breast may be important in prognosis and treatment selection.
回顾了12例乳腺单纯腺样囊性癌病例。患者年龄在34至69岁之间。7例癌位于右乳，5例位于左乳；12例中的5例位于乳腺中央区，5例位于外上象限，2例分别位于内上象限和内下象限。原发肿瘤的平均直径为2.5 cm（范围为0.7至6.0）。我们根据用于唾液腺腺样囊性癌的系统对肿瘤进行分级：5例肿瘤为I级，6例为II级，1例为III级。诊断后平均5年，所有I级肿瘤患者要么存活且无疾病证据，要么死于无关原因。在6例II级肿瘤患者中，1例在诊断后5年出现局部复发并随后发生肺转移，1例在诊断后13年死于转移性腺样囊性癌。1例III级肿瘤患者在乳房切除时已出现腋窝淋巴结转移，2年后死于该疾病。这些发现表明，乳腺腺样囊性癌的分级在预后和治疗选择中可能很重要。
