Department of Breast Surgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Burn Plastic Surgery, Chaoyang Central Hospital, Chaoyang, Liaoning, China.
BMC Surg. 2022 Mar 24;22(1):113. doi: 10.1186/s12893-022-01560-9.
Primary adenoid cystic carcinoma (ACC) of breast is rarely seen clinically. It is a special subtype of triple-negative breast cancer characterized by low expression of Ki-67, low malignant potential, slow progression and favorable prognosis. To date, treatment for this disease is controversial and no consensus is reached. We analyzed clinical manifestations and pathological characteristics of seven primary breast ACC cases and reported in combination with literature review to promote understanding, diagnosis and treatment of this disease.
We collected seven breast ACC cases pathologically diagnosed and treated in Department of breast surgery of the First Affiliated Hospital of China Medical University from January 2015 to December 2018. We organized and summarized the clinical, imaging, pathological and prognostic information and performed statistical analysis. The median age was 60 years (ranging from 54 to 64 years). Tumors of all patients were detected by immunohistochemistry. Molecular types were mostly triple negative (4/7), and Ki-67 expression was low (5/7). Lymph node metastases were absent in all patients received axillary lymph node surgery. Median follow-up time was 39 months (ranging from 25 to 68 months). There was no occurrence of relapse, distant metastasis or death.
Breast ACC is accompanied with favorable diagnosis, which is different from typical triple-negative breast cancer. Accurate diagnosis of ACC is particularly important.
乳腺原发性腺样囊性癌（ACC）临床上少见，是三阴性乳腺癌的一种特殊亚型，其 Ki-67 低表达、恶性潜能低、进展缓慢、预后良好。目前，对该疾病的治疗存在争议，尚无共识。我们分析了 7 例乳腺原发性 ACC 的临床表现和病理特征，并结合文献复习进行报道，以促进对该疾病的认识、诊断和治疗。
我们收集了 2015 年 1 月至 2018 年 12 月在中国医科大学附属第一医院乳腺外科经病理诊断为乳腺 ACC 的 7 例病例。我们对临床、影像学、病理学和预后信息进行了整理和总结，并进行了统计学分析。中位年龄为 60 岁（范围为 54-64 岁）。所有患者的肿瘤均通过免疫组织化学检测。分子类型多为三阴性（4/7），Ki-67 表达较低（5/7）。所有接受腋窝淋巴结清扫术的患者均无腋窝淋巴结转移。中位随访时间为 39 个月（范围为 25-68 个月）。无复发、远处转移或死亡发生。
乳腺 ACC 具有良好的诊断预后，与典型的三阴性乳腺癌不同。准确诊断 ACC 尤为重要。
