Drozd N N, Logvinova Yu S, Torlopov M A, Udoratina E V
National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
Institute of Chemistry, Komi Science Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
Bull Exp Biol Med. 2017 Feb;162(4):462-465. doi: 10.1007/s10517-017-3640-2. Epub 2017 Feb 27.
Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.
分子量为150和20 kDa的葡聚糖硫酸化（至2.8）后出现抗凝活性，该活性随分子量降低而增加，且不依赖于抗凝血酶，后者是血液凝固系统丝氨酸蛋白酶的血浆抑制剂。分子量为20 kDa的硫酸葡聚糖的抗凝血酶活性达到12.6 - 15.3 U/mg。分子量为20和150 kDa的硫酸葡聚糖不会增强ADP诱导的人血小板聚集。
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