Bleyer Archie, Ferrari Andrea, Whelan Jeremy, Barr Ronald D
Department of Radiation Medicine, Oregon Health and Sciences University, Portland, Oregon.
Department of Pediatrics, University of Texas Medical School at Houston, Houston, Texas.
Pediatr Blood Cancer. 2017 Sep;64(9). doi: 10.1002/pbc.26497. Epub 2017 Feb 28.
In high-income countries, cancer remains the commonest cause of disease-related death in adolescents and young adults (AYAs) despite survival improvements. With more than 1,000,000 new diagnoses of cancer in AYAs annually worldwide, and their number of life-years affected by cancer being greatest of all ages, the global burden of cancer in AYAs exceeds that in all other ages. In low- and middle-income countries, where the great majority of the world's 3 billion AYAs reside, the needs of those with cancer have been identified and demand attention. Unique to the age group but universal, the psychosocial challenges they face are the utmost across life's spectrum. This lead-off article of a new series in Pediatric Blood and Cancer on AYA oncology attempts to assess the global status of this emerging discipline. The review includes the changing incidence and survival of the common cancers in AYAs-there is no other age group with a similar array of malignancies-and the specific challenges to quality and quantity of life that compromise their lives.
在高收入国家，尽管癌症生存率有所提高，但它仍是青少年和青年（AYA）疾病相关死亡的最常见原因。全球每年有超过100万青少年和青年被新诊断出患有癌症，且他们受癌症影响的生命年数在所有年龄段中是最多的，因此全球青少年和青年的癌症负担超过了所有其他年龄段。在低收入和中等收入国家，全球30亿青少年和青年中的绝大多数居住于此，患癌人群的需求已得到确认并需要关注。他们面临的心理社会挑战在整个生命历程中极为突出，这是该年龄组独有的但又具有普遍性。《儿科血液与癌症》杂志关于青少年和青年肿瘤学的新系列文章的开篇之作，试图评估这一新兴学科的全球现状。该综述涵盖了青少年和青年常见癌症发病率和生存率的变化（没有其他年龄组有如此多样的恶性肿瘤）以及影响他们生活质量和寿命的具体挑战。
