Bhupornvivat Nalina, Phupong Vorapong
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Email:
Asia Pac J Clin Nutr. 2017 Mar;26(2):287-290. doi: 10.6133/apjcn.112015.11.
Pregnancy complications hypothesized to be related to vitamin D include preeclampsia, gestational diabetes, low birth weight, preterm delivery, Cesarean section and infectious disease. There have been a few studies which have demonstrated maternal serum vitamin D to be associated with preterm labor. The objective was to evaluate the serum vitamin D concentrations in Thai pregnant women with and without preterm labor and to find the prevalence of vitamin D deficiency and insufficiency in both groups.
Blood samples were collected from pregnant women with and without preterm labor (matched for gestational age). Serum 25-hydroxyvitamin D (25-OHD) concentrations were measured by chemiluminescence method.
A total of 60 pregnant women were included into the study, 30 patients in the preterm labor group and another 30 patients in the control group. The serum 25-OHD concentration was 21.0±7.5 ng/mL and the prevalence of vitamin D deficiency was 48.3% in total group of pregnant women. The serum 25-OHD concentrations were not different between the preterm labor and the control groups (20.9±8.4 vs 21.2±6.7 ng/mL, p=0.91). The prevalence of vitamin D deficiency and insufficiency were not different between the preterm labor and the control groups (53.3% vs 43.3%, p=0.44 and 83.3% vs 90%, p=0.45, respectively).
The serum 25-hydroxyvitamin D concentrations and the prevalence of vitamin D deficiency and insufficiency were not different between the preterm labor and the control groups. The serum 25-OHD could not predict preterm labor in this Thai population.
据推测，与维生素D相关的妊娠并发症包括先兆子痫、妊娠期糖尿病、低出生体重、早产、剖宫产及传染病。已有一些研究表明，孕妇血清维生素D与早产有关。本研究的目的是评估有早产和无早产的泰国孕妇的血清维生素D浓度，并找出两组中维生素D缺乏和不足的发生率。
收集有早产和无早产的孕妇（按孕周匹配）的血样。采用化学发光法测定血清25-羟维生素D（25-OHD）浓度。
共有60名孕妇纳入本研究，早产组30例，对照组30例。孕妇总群体血清25-OHD浓度为21.0±7.5 ng/mL，维生素D缺乏发生率为48.3%。早产组与对照组血清25-OHD浓度无差异（20.9±8.4 vs 21.2±6.7 ng/mL，p = 0.91）。早产组与对照组维生素D缺乏和不足的发生率无差异（分别为53.3% vs 43.3%，p = 0.44；83.3% vs 90%，p = 0.45）。
早产组与对照组血清25-羟维生素D浓度以及维生素D缺乏和不足的发生率无差异。在该泰国人群中，血清25-OHD无法预测早产。
