NFATC1基因分型影响接受环孢素治疗的肾移植受者的急性排斥反应和长期移植肾功能。
NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients.
作者信息
Xu Qinxia, Qiu Xiaoyan, Jiao Zheng, Zhang Ming, Chen Jianping, Zhong Mingkang
机构信息
Department of Pharmacy, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China.
Department of Nephrology, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China.
出版信息
Pharmacogenomics. 2017 Mar;18(4):381-392. doi: 10.2217/pgs-2016-0171. Epub 2017 Feb 17.
AIM
To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) on cyclosporine (CsA) efficacy in renal transplant recipients.
MATERIALS & METHODS: Seventy-six tag SNPs were detected in 155 CsA-treated renal recipients with at least a 5-year follow-up. The associations of SNPs with acute rejection, nephrotoxicity, pneumonia and estimated glomerular filtration rate post transplant were explored.
RESULTS
NFATC1 rs3894049 GC was a risk factor for acute rejection compared with CC carriers (p = 0.0005). NFATC1 rs2280055 TT carriers had a more stable estimated glomerular filtration rate level than CC (p = 0.0004).
CONCLUSION
Detecting NFATC1 polymorphisms could help predict CsA efficacy in renal transplant patients.
目的
研究亲环素A/钙调神经磷酸酶/活化T细胞核因子（NFATs）通路基因（PPIA、PPP3CB、PPP3R1、NFATC1和NFATC2）中的单核苷酸多态性（SNPs）对肾移植受者环孢素（CsA）疗效的影响。
材料与方法
在155例接受CsA治疗且至少随访5年的肾移植受者中检测了76个标签SNPs。探讨了SNPs与急性排斥反应、肾毒性、肺炎及移植后估计肾小球滤过率的相关性。
结果
与携带CC的患者相比，NFATC1 rs3894049位点的GC基因型是急性排斥反应的危险因素（p = 0.0005）。携带NFATC1 rs2280055位点TT基因型的患者其估计肾小球滤过率水平比携带CC基因型的患者更稳定（p = 0.0004）。
结论
检测NFATC1基因多态性有助于预测肾移植患者的CsA疗效。
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