Xu Qin-Xia, Qiu Xiao-Yan, Jiao Zheng, Zhang Ming, Zhong Ming-Kang
Department of Pharmacy, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Department of Pharmacy, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Gene. 2018 Feb 20;644:93-100. doi: 10.1016/j.gene.2017.10.081. Epub 2017 Oct 31.
The present study was conducted to determine the effect of FOXP3 single nucleotide polymorphisms (SNPs) on clinical outcomes in CsA-treated renal transplant patients.
A total of 166 renal transplant patients with at least 5years of follow-up were included. SNPs of FOXP3 gene (rs3761547, rs3761548, rs3761549, rs2232365 and rs2280883) were detected by Taqman probe technique. The associations of SNPs with acute rejection, CsA-induced nephrotoxicity, pneumonia and post-transplantation estimated glomerular filtration rate (eGFR) were explored.
Patients with rs3761549 T/TT genotype showed a more rapid decline in the eGFR level during the 5years following transplantation than those with the C/CC genotype (24.0% vs. 6.3%, P=0.004). All the SNPs and site-site interaction were not related to the occurrence of acute rejection, nephrotoxicity, and pneumonia.
FOXP3 rs3761549 was significantly correlated with the renal allograft function. It could be used to predict and improve the outcome of renal transplant patients taking CsA as an immunosuppressant.
本研究旨在确定FOXP3单核苷酸多态性（SNP）对接受环孢素A（CsA）治疗的肾移植患者临床结局的影响。
纳入166例至少随访5年的肾移植患者。采用Taqman探针技术检测FOXP3基因的SNP（rs3761547、rs3761548、rs3761549、rs2232365和rs2280883）。探讨SNP与急性排斥反应、CsA诱导的肾毒性、肺炎及移植后估计肾小球滤过率（eGFR）的相关性。
rs3761549 T/TT基因型患者在移植后5年内eGFR水平下降速度比C/CC基因型患者更快（24.0%对6.3%，P = 0.004）。所有SNP及位点间相互作用均与急性排斥反应、肾毒性和肺炎的发生无关。
FOXP3 rs3761549与肾移植功能显著相关。它可用于预测和改善以CsA作为免疫抑制剂的肾移植患者的结局。
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