Chen Li, Sun Ke Xin, Juan Juan, Fang Kai, Liu Kuo, Wang Xue Yin, Wang Ling, Yang Chao, Liu Xiao Qiang, Li Jing, Tang Xun, Wu Yi Qun, Qin Xue Ying, Wu Tao, Chen Da Fang, Hu Yong Hua
Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Biomed Environ Sci. 2017 Jan;30(1):35-43. doi: 10.3967/bes2017.004.
To understand the relationships between CDH13 (T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors.
We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight (HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model.
In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels (per T: Coef = -0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels (per A: Coef = -0.221, P = 0.001) and HMW adiponectin levels (per A: Coef = -0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke (GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction (α = 0.025). There was an interaction between rs7193788 and diabetes (P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke (OR = 2.64, 95% CI: 1.58-4.40, P < 0.001).
CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke.
了解CDH13（T-钙黏蛋白）基因多态性、脂联素水平与缺血性卒中之间的关系，以及CDH13基因多态性与其他危险因素之间可能存在的相互作用。
我们招募了342对中国缺血性卒中同胞对。使用飞行时间质谱基因分型技术对CDH13上的rs4783244和rs7193788进行基因分型，并测量总脂联素和高分子量（HMW）脂联素水平。我们使用多级混合效应回归模型研究单核苷酸多态性（SNP）与缺血性卒中之间的关联，以及SNP与其他危险因素之间的相互作用。
在无缺血性卒中的个体中，CDH13 rs4783244与总脂联素水平相关（每一个T：系数=-0.257，P=0.001）。CDH13 rs7193788与总脂联素水平相关（每一个A：系数=-0.221，P=0.001）以及与HMW脂联素水平相关（每一个A：系数=-0.163，P=0.003）。经过Bonferroni校正（α=0.025）后，rs7193788与缺血性卒中显著相关（GA/AA与GG相比：比值比=1.55，95%可信区间：1.07至2.24，P=0.020）。rs7193788与糖尿病之间存在相互作用（P=0.036）。与rs7193788 GG基因型的无糖尿病个体相比，rs7193788 GA/AA基因型的糖尿病患者发生缺血性卒中的风险更高（比值比=2.64，95%可信区间：1.58 - 4.40，P<0.001）。
CDH13基因多态性与脂联素水平及缺血性卒中相关。发现CDH13 SNP与糖尿病在缺血性卒中方面存在相互作用。
