脂联素基因多态性与缺血性中风风险相关：一项荟萃分析。

Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis.

作者信息

Shen Dingzhu, Xing Sanli, Chen Chuan

机构信息

Shanghai Geriatric Institute of Chinese Medicine, Longhua Hospital Affiliated Shanghai University of Traditional Chinese Medicine, P.R. China

Shanghai Geriatric Institute of Chinese Medicine, Longhua Hospital Affiliated Shanghai University of Traditional Chinese Medicine, P.R. China.

出版信息

J Renin Angiotensin Aldosterone Syst. 2015 Mar;16(1):178-84. doi: 10.1177/1470320314552311. Epub 2014 Dec 12.

DOI:10.1177/1470320314552311

PMID:25501307

Abstract

BACKGROUND

Previous studies have reported the relation between the adiponectin polymorphisms and the risk of ischemic stroke. However, the findings is inclusive. In the present study, we performed a meta-analysis to clarify the relation between the adiponectin polymorphisms and the stroke.

METHODS

Relevant studies were identified by searching PubMed, EMBASE, ISI Web of Science, ScienceDirect, Wiley Online Library, Wanfang database in China, and Chinese National Knowledge Infrastructure databases (CNKI) through July 2013 and other method such as reviewing the reference of retrieved literatures. We selected literatures that reported Odds ratio (OR) and 95% confidence interval (CI) for the relation between the ischemic stroke and the adiponectin genetic polymorphisms. With 1720 stroke cases and 5549 controls, were included. Our results showed that rs2241766 was associated with the risk of ischemic stroke in a recessive model (GG vs (TT+TG), OR = 1.29, 95% CI: 1.01-1.64, p = 0.04). However, rs1501299 and rs266729 were not found to be associated with ischemic stroke in our analysis.

CONCLUSION

The present study suggested that rs2241766 polymorphism of adiponectin gene was associated with the risk for ischemic stroke.

摘要

背景

既往研究报道了脂联素基因多态性与缺血性卒中风险之间的关系。然而，研究结果并不一致。在本研究中，我们进行了一项荟萃分析以阐明脂联素基因多态性与卒中之间的关系。

方法

通过检索PubMed、EMBASE、ISI科学网、ScienceDirect、Wiley在线图书馆、中国万方数据库以及中国知网数据库，截止至2013年7月，识别相关研究，并通过查阅检索文献的参考文献等其他方法进行补充。我们选择了报告缺血性卒中和脂联素基因多态性之间关系的比值比（OR）和95%置信区间（CI）的文献。纳入了1720例卒中病例和5549例对照。我们的结果显示，在隐性模型中，rs2241766与缺血性卒中风险相关（GG与（TT+TG）相比，OR = 1.29，95% CI：1.01 - 1.64，p = 0.04）。然而，在我们的分析中，未发现rs1501299和rs266729与缺血性卒中相关。