Petrovicová A, Cervenka J, Egnerová A
Research Institute of Preventive Medicine, Bratislava, Czechoslovakia.
J Hyg Epidemiol Microbiol Immunol. 1987;31(3):251-7.
The frequency of actual infections by selected types of coxsackie virus (B1-B6, A7, A9) has been followed up in adult patients hospitalized for reason of heart disease. Criteria of actual coxsackie virus infection have been defined, including a significant rise of titer of virus neutralizing antibodies and/or presence of virus-specific IgM antibodies. An actual coxsackie virus infection has been found in 71 (46.3%) out of 153 patients. Most frequently coxsackie B1 virus infection (24 times) and B4 (17 times) could be proved. In sera of patients with actual coxsackie virus infection, a higher proportion of infection with some types of coxsackie viruses, along with the presence of antibodies against a larger number of coxsackie virus types has been found, as compared to sera from patients without actual coxsackie virus infection, and/or, in sera of healthy blood donors (control group). The role of repeated infections with different types of coxsackie virus in the etiology of heart disease has been discussed.
对因心脏病住院的成年患者中选定类型的柯萨奇病毒（B1 - B6、A7、A9）实际感染频率进行了随访。已确定实际柯萨奇病毒感染的标准，包括病毒中和抗体滴度显著升高和/或存在病毒特异性IgM抗体。在153名患者中，有71名（46.3%）被发现存在实际的柯萨奇病毒感染。最常被证实的是柯萨奇B1病毒感染（24次）和B4病毒感染（17次）。与无实际柯萨奇病毒感染患者的血清和/或健康献血者（对照组）的血清相比，在有实际柯萨奇病毒感染患者的血清中，发现某些类型柯萨奇病毒的感染比例更高，同时存在针对更多柯萨奇病毒类型的抗体。文中讨论了不同类型柯萨奇病毒反复感染在心脏病病因学中的作用。
