[柯萨奇B病毒感染与心脏疾病]

[Coxsackie B virus infection and cardiopathies].

作者信息

Santoro R, Rapicetta M, Mancini G, Pietropaolo C

出版信息

Boll Ist Sieroter Milan. 1977 Jul 31;56(3):282-7.

Abstract

Neutralizing antibody activity against Coxsackie virus group B, types 1-6, was determined on paired serum samples taken from 16 hospitalized patients affected by acute heart diseases of suspected viral origin. Serum samples were also taken from 4 additional cases of pleuropericarditis observed in the course of a small outbreak of Coxsackie B2 infection. Serological evidence of virus infection was based on the occurrence of the following conditions: a) twofold or greater variation of virus neutralizing antibody; b) antibody titers equal to or greater than 1:256. Evidence of Coxsackie B2 virus infection was found in 12 patients, while Coxsackievirus B1, B3, B5 and B6 infection, respectively, could be associated with 4 cases. The advisability of performing serological examination for Coxsackie group B viruses antibodies in patients with heart diseases of suspected viral origin is emphasized.

摘要

对16例疑似病毒源性急性心脏病住院患者采集的配对血清样本，测定了针对1 - 6型B组柯萨奇病毒的中和抗体活性。还从在一次小型柯萨奇B2感染暴发过程中观察到的另外4例胸膜心包炎病例采集了血清样本。病毒感染的血清学证据基于以下情况的出现：a）病毒中和抗体有两倍或更大的变化；b）抗体滴度等于或大于1:256。在12例患者中发现了柯萨奇B2病毒感染的证据，而柯萨奇病毒B1、B3、B5和B6感染分别与4例病例相关。强调了对疑似病毒源性心脏病患者进行B组柯萨奇病毒抗体血清学检查的必要性。