Doutremepuich C, Toulemonde F, de Seze O, Pereira F, Anne M C, Doutremepuich F
Laboratoire d' Hématologie, Université de Bordeaux II, France.
J Leukoc Biol. 1987 Dec;42(6):628-31. doi: 10.1002/jlb.42.6.628.
A randomized study was performed to observe the effects induced by heparin and a low molecular weight heparin fraction (at different dosages) on the leukocytes of rats in the presence of experimental venous thrombosis. The experimentation was carried out on two series of animals: the first with a ligature of the inferior vena cava inducing the formation of a thrombus, the second without any ligature. The results show that the induction of thrombosis involves: in the blood, an increase of the number leukocytes, principally polymorphonuclear cells; in the thrombi, a significant rise in the total count of leukocytes, here mononuclear cells; the latter number increases with the dosages of the administered drugs.
进行了一项随机研究，以观察肝素和低分子量肝素组分（不同剂量）在实验性静脉血栓形成情况下对大鼠白细胞的影响。实验在两组动物上进行：第一组通过结扎下腔静脉诱导血栓形成，第二组不进行任何结扎。结果表明，血栓形成的诱导涉及：在血液中，白细胞数量增加，主要是多形核细胞；在血栓中，白细胞总数显著增加，此处为单核细胞；后者的数量随着给药剂量的增加而增加。
