Doutremepuich C, Gestreau J L, Maury M O, Quilichini R, Boisseau M R, Toulemonde F, Vairel E
Haemostasis. 1983;13(2):109-12. doi: 10.1159/000214713.
An unfractionated mucosal heparin preparation and a low molecular weight heparin fraction were randomly administered to rats subcutaneously. This injection was made on rats with experimentally induced venous thrombosis. At high doses (6.66 mg/kg) of both drugs, thrombus mean weight was reduced in comparison with a control group. At lower doses (2.22 mg/kg) these two drugs inhibited the growth of the thrombus. This inhibition was obtained with a lower dose (0.66 mg/kg) of the low molecular weight heparin fraction than of heparin. The low molecular weight heparin fraction (molecular weight 5,000 daltons) has a high anti-Xa activity (200 units) and a low activity determined by the USP assay (50 units).
将未分级的黏膜肝素制剂和低分子量肝素组分随机皮下注射给大鼠。对实验性诱导静脉血栓形成的大鼠进行该注射。两种药物在高剂量（6.66毫克/千克）时，与对照组相比，血栓平均重量降低。在较低剂量（2.22毫克/千克）时，这两种药物抑制血栓生长。低分子量肝素组分以比肝素更低的剂量（0.66毫克/千克）获得这种抑制效果。低分子量肝素组分（分子量5000道尔顿）具有高抗Xa活性（200单位）和由美国药典测定法确定的低活性（50单位）。
