Nicula Renata, Diculescu Doru, Lencu Codruţa Claudia, Ciortea Răzvan, Bucuri Carmen Elena, Oltean Ioana Adriana, Trif Ioana Alexandra, Mihu Dan
2nd Department of Obstetrics-Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Clujul Med. 2017;90(1):33-39. doi: 10.15386/cjmed-670. Epub 2017 Jan 15.
Perimenopause is marked by clinical manifestations which disturb everyday life and which may also hide a pathomorphological, more precisely endometrial, substrate. An accurate early diagnosis established by accessible, non-invasive methods is very important for the therapeutic management.
The study included 103 patients aged between 41.5-55.11 years, divided into 3 age groups: 40-44 years (n=10), 45-49 years (n=54) and ≥50 years (n=39).
Certain risk factors of endometrial neoplasm or premalignant conditions were evidenced, their accurate identification being useful in limiting the number of patients with abnormal uterine bleeding (AUB) submitted to diagnostic screening. The most common cause of AUB in our study was fibroma, followed by functional causes.
Transvaginal ultrasound (TVUS) represents a minimally invasive method for the screening of perimenopausal patients with AUB, especially to rule out endometrial adenocarcinoma (EAC). TVUS sensitivity was higher than clinical diagnosis in case of leiomioma, polypi and EAC. TVUS was more accurate in the diagnosis of EAC, polypi and leiomioma.
围绝经期的特征是出现干扰日常生活的临床表现，这些表现可能还隐藏着病理形态学基础，更确切地说是子宫内膜方面的基础。通过可及的非侵入性方法进行准确的早期诊断对治疗管理非常重要。
该研究纳入了103例年龄在41.5 - 55.11岁之间的患者，分为3个年龄组：40 - 44岁（n = 10）、45 - 49岁（n = 54）和≥50岁（n = 39）。
证实了子宫内膜肿瘤或癌前病变的某些危险因素，准确识别这些因素有助于减少接受诊断性筛查的异常子宫出血（AUB）患者数量。在我们的研究中，AUB最常见的原因是纤维瘤，其次是功能性原因。
经阴道超声（TVUS）是一种对有AUB的围绝经期患者进行筛查的微创方法，尤其用于排除子宫内膜腺癌（EAC）。在平滑肌瘤、息肉和EAC的情况下，TVUS的敏感性高于临床诊断。TVUS在EAC、息肉和平滑肌瘤的诊断中更准确。
