Carbone Laura D, Bůžková Petra, Fink Howard A, Robbins John A, Bethel Monique, Hamrick Mark W, Hill William D
Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
Department of Medicine, Medical College of Georgia, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Augusta, GA, USA.
Calcif Tissue Int. 2017 Jun;100(6):599-608. doi: 10.1007/s00223-017-0245-8. Epub 2017 Feb 28.
Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.
衰老与循环炎症因子增加相关。其中一种细胞因子，即基质细胞衍生因子1（SDF-1或CXCL12），对干细胞动员、迁移和归巢以及对骨髓干细胞（BMSC）、成骨细胞和破骨细胞功能至关重要。SDF-1在骨形成以及BMSC向成骨细胞/骨细胞分化和骨祖细胞存活方面具有多效性作用。本研究的目的是在心血管健康研究（CHS）参与者中检测血浆SDF-1与骨密度（BMD）、身体组成和髋部骨折发生率之间的关联。在1536名CHS参与者中，SDF-1血浆水平与年龄增长（p<0.01）和男性性别（p = 0.04）显著相关，但与种族无关（p = 0.63）。在多变量调整模型中，较高的SDF-1水平与较低的全髋BMD相关（p = 0.02）。然而，SDF-1与髋部骨折无显著关联（p = 0.53）。总之，SDF-1的循环血浆水平与年龄增长相关，并且在男性和女性中均独立与较低的全髋BMD相关。这些发现表明SDF-1水平与骨稳态相关。
