Carthy Jonathon M
Faculty of Medicine, Division of Brain Sciences, Imperial College London, London, UK.
J Cell Physiol. 2018 Jan;233(1):98-106. doi: 10.1002/jcp.25879. Epub 2017 May 15.
The myofibroblast is a highly specialized cell type that plays a critical role during normal tissue wound healing, but also contributes pathologically to chronic inflammatory conditions such as fibrosis and cancer. As fibrotic conditions continue to be a major burden to the public health system, novel therapies that target the function of myofibroblasts may show promise in the clinic. The cytokine transforming growth factor β (TGFβ) is the most potent known inducer of myofibroblast differentiation and thus represents a powerful target to modify myofibroblast function during disease. This review focuses on our current understanding of the key signaling pathways activated by TGFβ during myofibroblast differentiation.
肌成纤维细胞是一种高度特化的细胞类型，在正常组织伤口愈合过程中发挥关键作用，但在诸如纤维化和癌症等慢性炎症性疾病中也具有病理作用。由于纤维化疾病仍然是公共卫生系统的主要负担，针对肌成纤维细胞功能的新型疗法可能在临床上显示出前景。细胞因子转化生长因子β（TGFβ）是已知最有效的肌成纤维细胞分化诱导剂，因此是在疾病期间改变肌成纤维细胞功能的有力靶点。本综述聚焦于我们目前对TGFβ在肌成纤维细胞分化过程中激活的关键信号通路的理解。
