Leung D W, Spencer S A, Cachianes G, Hammonds R G, Collins C, Henzel W J, Barnard R, Waters M J, Wood W I
Department of Developmental Biology, Genentech, Inc., South San Francisco, California.
Nature. 1987;330(6148):537-43. doi: 10.1038/330537a0.
A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.
来自兔肝脏的一种假定生长激素受体和兔血清中的生长激素结合蛋白具有相同的氨基末端氨基酸序列，这表明该结合蛋白对应于肝脏受体的细胞外激素结合结构域。从编码假定的人和兔生长激素受体的互补DNA克隆推导的完整氨基酸序列与其他已知蛋白质不相似，这证明了一类新的跨膜受体。
