Rodriguez F J, Gil V, del Carmen Beneyto M, Lopez-Vidriero E
Section of Hypertension, Provincial Hospital, 28007 Madrid, Spain.
Postgrad Med J. 1986;62 Suppl 1:94-6.
An investigation of the therapeutic effect of a once daily dose of captopril was carried out on 19 patients with essential hypertension. Captopril was administered at a dose of 50 mg/day for 2 weeks. If blood pressure was not reduced to less than 160/95 mm Hg in that time, the dose was increased to 100 mg/day for a further 2 weeks (5 patients). If blood pressure remained high, 50 mg chlorthalidone/day was added (4 patients). Only 1 patient was not controlled. The drugs were administered in the morning. Blood pressure and serum angiotensin converting enzyme activity (SACE) were measured 24 hours after the last dose, and patients were followed up to 3 months. The basal SACE decreased 24 hours after the first captopril dose but 3 months later, when blood pressure was controlled, the mean level was back to baseline values. Our results show that once-daily captopril is efficacious in hypertension and its hypotensive effect appears to be independent of ACE inhibition.
对19例原发性高血压患者进行了每日一次剂量卡托普利治疗效果的研究。卡托普利以50毫克/天的剂量给药，持续2周。如果在此期间血压未降至160/95毫米汞柱以下，则剂量增加至100毫克/天，再持续2周（5例患者）。如果血压仍然很高，则加用每日50毫克氢氯噻嗪（4例患者）。只有1例患者血压未得到控制。药物于早晨给药。在最后一剂后24小时测量血压和血清血管紧张素转换酶活性（SACE），并对患者进行3个月的随访。首次服用卡托普利后24小时基础SACE下降，但3个月后，当血压得到控制时，平均水平恢复到基线值。我们的结果表明，每日一次服用卡托普利对高血压有效，其降压作用似乎与ACE抑制无关。
