Frewin D B, Buik C, Rennie G
Department of Clinical Pharmacology, Royal Adelaide Hospital, Australia.
Eur J Clin Pharmacol. 1989;36(1):11-5. doi: 10.1007/BF00561016.
Twelve patients with essential hypertension receiving captopril monotherapy or captopril in conjunction with a diuretic had their 24-h blood pressure profiles monitored using an automatic, non-invasive ambulatory method. The study examined the efficacy of once a day versus twice a day administration of the ACE inhibitor in controlling blood pressure. Six untreated subjects with borderline hypertension were also studied using the same monitoring equipment and with the same frequency, to act as controls because of the possibility of repeated use of the device causing a 'familiarisation' effect. The results obtained indicated that if anything, the once daily dosing produced marginally better blood pressure values. The amplitude of the diurnal blood pressure variation was reduced on a 'second-wearing' of the monitoring equipment suggesting some degree of familiarisation with the apparatus.
12例接受卡托普利单一疗法或卡托普利与利尿剂联合治疗的原发性高血压患者，采用自动、无创的动态监测方法监测其24小时血压情况。该研究考察了血管紧张素转换酶抑制剂一日一次给药与一日两次给药在控制血压方面的疗效。还对6例临界高血压的未治疗受试者使用相同的监测设备并以相同频率进行研究，作为对照，因为重复使用该设备可能会产生“熟悉”效应。获得的结果表明，一日一次给药在降低血压值方面略好。在监测设备“第二次佩戴”时，昼夜血压变化幅度减小，这表明对该设备有一定程度的熟悉。
