Low C-F, Rozaini M Z H, Musa N, Syarul Nataqain B
Institute of Systems Biology, Universiti Kebangsaan Malaysia, Selangor, Malaysia.
Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Terengganu, Malaysia.
J Fish Dis. 2017 Oct;40(10):1267-1277. doi: 10.1111/jfd.12610. Epub 2017 Mar 2.
The approaches of transcriptomic and proteomic have been widely used to study host-pathogen interactions in fish diseases, and this is comparable to the recently emerging application of metabolomic in elucidating disease-resistant mechanisms in fish that gives new insight into potential therapeutic strategies to improve fish health. Metabolomic is defined as the large-scale study of all metabolites within an organism and represents the frontline in the 'omics' approaches, providing direct information on the metabolic responses and perturbations in metabolic pathways. In this review, the current research in infectious fish diseases using metabolomic approach will be summarized. The metabolomic approach in economically important fish infected with viruses, bacteria and nematodes will also be discussed. The potential of the metabolomic approach for management of these infectious diseases as well as the challenges and the limitations of metabolomic in fish disease studies will be explored. Current review highlights the impacts of metabolomic studies in infectious fish diseases, which proposed the potential of new therapeutic strategies to enhance disease resistance in fish.
转录组学和蛋白质组学方法已被广泛用于研究鱼类疾病中的宿主-病原体相互作用，这与最近代谢组学在阐明鱼类抗病机制方面的新兴应用相当，后者为改善鱼类健康的潜在治疗策略提供了新的见解。代谢组学被定义为对生物体中所有代谢物的大规模研究，是“组学”方法的前沿领域，提供有关代谢反应和代谢途径扰动的直接信息。在这篇综述中，将总结目前使用代谢组学方法对感染性鱼类疾病的研究。还将讨论在感染病毒、细菌和线虫的经济重要鱼类中使用代谢组学方法的情况。将探索代谢组学方法在管理这些传染病方面的潜力以及代谢组学在鱼类疾病研究中的挑战和局限性。当前的综述强调了代谢组学研究对感染性鱼类疾病的影响，提出了增强鱼类抗病性的新治疗策略的潜力。
