一种用于眼表金黄色葡萄球菌感染的小鼠模型。
A Mouse Model for Ocular Surface Staphylococcus aureus Infection.
作者信息
Zhang Zhiyong, Abdel-Razek Osama, Wang Guirong
机构信息
Department of Surgery, The State University of New York Upstate Medical University, Syracuse, New York.
Department of Ophthalmology, Zhejiang Medical College Affiliated Zhejiang Hospital, Hangzhou, Zhejiang, People's Republic of China.
出版信息
Curr Protoc Mouse Biol. 2017 Mar 2;7(1):55-63. doi: 10.1002/cpmo.23.
Creation of an appropriate animal model that accurately reflects the disease and host immune response to bacterial infection in humans is a major challenge in ocular-surface infection research. For decades, mice have been the ideal small animal model for ocular-surface infection research because of the availability and relatively low cost of various genetic backgrounds, targeted defects, and immunologic reagents. By employing different combinations of mouse and bacterial strains, murine infection models can be used to explore a complete picture of bacterial infection and innate immunity of the ocular surface. A murine model of Staphylococcus aureus infection under normal ocular circumstances is presented here as a convenient and tractable model system in which to study mammalian host responses to pathogens. © 2017 by John Wiley & Sons, Inc.
创建一个能准确反映人类眼部表面细菌感染疾病及宿主免疫反应的合适动物模型，是眼部表面感染研究中的一项重大挑战。几十年来，小鼠一直是眼部表面感染研究的理想小动物模型，这是因为有各种不同基因背景、靶向缺陷和免疫试剂可供使用，且成本相对较低。通过采用小鼠和细菌菌株的不同组合，鼠类感染模型可用于全面探究眼部表面的细菌感染和先天免疫。本文介绍了一种正常眼部情况下金黄色葡萄球菌感染的鼠类模型，它是一种方便且易于操作的模型系统，可用于研究哺乳动物宿主对病原体的反应。© 2017 约翰威立国际出版公司
Zotero 插件