Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Trends Microbiol. 2016 Nov;24(11):872-886. doi: 10.1016/j.tim.2016.06.012. Epub 2016 Jul 26.
Staphylococcus aureus persistently colonizes the anterior nares of approximately one fifth of the population and nasal carriage is a significant risk factor for infection. Recent advances have significantly refined our understanding of S. aureus-host communication during nasal colonization. Novel bacterial adherence mechanisms in the nasal epithelium have been identified, and novel roles for both the innate and the adaptive immune response in controlling S. aureus nasal colonization have been defined, through the use of both human and rodent models. It is clear that S. aureus maintains a unique, complex relationship with the host immune system and that S. aureus nasal colonization is overall a multifactorial process which is as yet incompletely understood.
金黄色葡萄球菌持续定植于大约五分之一人口的前鼻腔，而鼻腔携带是感染的重要危险因素。最近的进展显著地改善了我们对金黄色葡萄球菌在鼻腔定植期间与宿主间通讯的理解。通过使用人类和啮齿动物模型，已经鉴定出鼻上皮中的新型细菌黏附机制，以及固有和适应性免疫反应在控制金黄色葡萄球菌鼻腔定植中的新型作用。很明显，金黄色葡萄球菌与宿主免疫系统维持着独特而复杂的关系，而金黄色葡萄球菌鼻腔定植总体上是一个多因素的过程，目前还不完全了解。
