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Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.

作者信息

Ipp Eli, Genter Pauline, Childress Kristin

机构信息

Harbor–UCLA Medical Center, Torrance, CA.

Los Angeles Biomedical Research Institute, Torrance, CA

出版信息

N Engl J Med. 2017 Mar 2;376(9):890-1. doi: 10.1056/NEJMc1615712.

DOI:10.1056/NEJMc1615712
PMID:28252263
Abstract
摘要

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1
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.
N Engl J Med. 2017 Mar 2;376(9):890-1. doi: 10.1056/NEJMc1615712.
2
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.司美格鲁肽与2型糖尿病患者的心血管结局
N Engl J Med. 2017 Mar 2;376(9):891-2. doi: 10.1056/NEJMc1615712.
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Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.
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Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.
N Engl J Med. 2017 Mar 2;376(9):890. doi: 10.1056/NEJMc1615712.
5
Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.口服司美格鲁肽与 2 型糖尿病患者的心血管结局。
N Engl J Med. 2019 Aug 29;381(9):841-851. doi: 10.1056/NEJMoa1901118. Epub 2019 Jun 11.
6
Will oral semaglutide be used to reduce cardiovascular risk in subjects with type 2 diabetes instead of subcutaneous semaglutide?口服司美格鲁肽是否会被用于降低 2 型糖尿病患者的心血管风险,而不是皮下注射司美格鲁肽?
Expert Opin Biol Ther. 2020 May;20(5):489-492. doi: 10.1080/14712598.2020.1724952. Epub 2020 Feb 5.
7
Semaglutide: Review and Place in Therapy for Adults With Type 2 Diabetes.司美格鲁肽:用于治疗成人 2 型糖尿病的药物评价及临床应用。
Can J Diabetes. 2019 Mar;43(2):136-145. doi: 10.1016/j.jcjd.2018.05.008. Epub 2018 Jun 5.
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Efficacy and safety of once-weekly semaglutide for the treatment of type 2 diabetes.每周一次司美格鲁肽治疗 2 型糖尿病的疗效和安全性。
Expert Opin Investig Drugs. 2017 Sep;26(9):1083-1089. doi: 10.1080/13543784.2017.1360274. Epub 2017 Aug 2.
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Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.替尔泊肽与司美格鲁肽每周一次治疗 2 型糖尿病患者的疗效比较。
N Engl J Med. 2021 Aug 5;385(6):503-515. doi: 10.1056/NEJMoa2107519. Epub 2021 Jun 25.
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Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea: The PIONEER 3 Randomized Clinical Trial.在单独使用二甲双胍或磺酰脲类药物控制不佳的 2 型糖尿病成人中,额外口服司美格鲁肽对比西格列汀对糖化血红蛋白的影响:PIONEER 3 随机临床试验。
JAMA. 2019 Apr 16;321(15):1466-1480. doi: 10.1001/jama.2019.2942.

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Inflammatory and metabolic markers mediate the association of hepatic steatosis and fibrosis with 10-year ASCVD risk.炎症和代谢标志物介导肝脂肪变性和肝纤维化与10年动脉粥样硬化性心血管疾病(ASCVD)风险之间的关联。
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Long-term efficacy of daily oral semaglutide as add-on or switch therapy in adults with type 2 diabetes: a 12-month real-world retrospective study.每日口服司美格鲁肽作为成人2型糖尿病附加治疗或转换治疗的长期疗效:一项为期12个月的真实世界回顾性研究。
Acta Diabetol. 2025 Feb 27. doi: 10.1007/s00592-025-02475-6.
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The long-term cost-effectiveness of once-weekly semaglutide versus sitagliptin for the treatment of type 2 diabetes in China.
在中国,每周一次司美格鲁肽与西格列汀治疗2型糖尿病的长期成本效益分析。
Health Econ Rev. 2024 Apr 2;14(1):26. doi: 10.1186/s13561-024-00499-2.
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Evaluating the bioequivalence and safety of liraglutide injection Victoza in healthy Chinese subjects: a randomized, open, two-cycle, self-crossover phase I clinical trial.评估利拉鲁肽注射液(维格列汀)在健康中国受试者中的生物等效性和安全性:一项随机、开放、两周期、自身交叉的I期临床试验。
Front Pharmacol. 2023 Dec 22;14:1326865. doi: 10.3389/fphar.2023.1326865. eCollection 2023.
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Polyethylene Glycol Loxenatide Injection (GLP-1) Protects Vascular Endothelial Cell Function in Middle-Aged and Elderly Patients With Type 2 Diabetes by Regulating Gut Microbiota.聚乙二醇洛塞那肽注射液(GLP-1)通过调节肠道菌群保护中老年2型糖尿病患者血管内皮细胞功能。
Front Mol Biosci. 2022 Jun 15;9:879294. doi: 10.3389/fmolb.2022.879294. eCollection 2022.
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Cardiovasc Diabetol. 2022 May 14;21(1):74. doi: 10.1186/s12933-022-01516-6.
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Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus: from pathophysiology to therapeutics.2型糖尿病中射血分数保留的心力衰竭(HFpEF):从病理生理学到治疗方法
J Mol Cell Biol. 2022 Sep 12;14(5). doi: 10.1093/jmcb/mjac028.
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Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-Like Peptide-1 Receptor Agonists, and Dipeptidyl Peptidase-4 Inhibitors, and Risk of Hospitalization.钠-葡萄糖共转运蛋白 2 抑制剂、胰高血糖素样肽-1 受体激动剂和二肽基肽酶-4 抑制剂与住院风险。
Am J Cardiol. 2022 Feb 15;165:124-130. doi: 10.1016/j.amjcard.2021.11.013. Epub 2021 Dec 20.
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Exploring the Appropriate Price of Semaglutide for Type 2 Diabetes Patients Based on Cost-Utility Analysis in China.基于中国成本-效用分析探索司美格鲁肽对2型糖尿病患者的合理价格
Front Pharmacol. 2021 Jun 10;12:701446. doi: 10.3389/fphar.2021.701446. eCollection 2021.
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GLP-1 alleviates NLRP3 inflammasome-dependent inflammation in perivascular adipose tissue by inhibiting the NF-κB signalling pathway.胰高血糖素样肽-1通过抑制核因子κB信号通路减轻血管周围脂肪组织中NLRP3炎性小体依赖性炎症。
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