Golovatskiĭ I D, Tsegel'skiĭ A A
Ukr Biokhim Zh (1978). 1987 Sep-Oct;59(5):45-9.
Different phosphate concentrations were studied for their effect on the degradation of adenosine by rat liver homogenates. It is shown that phosphate considerably inhibits the phosphoribomutase reaction without a significant effect on adenosine deaminase and purine nucleoside phosphorylase activities, that leads to the ribose-1-phosphate accumulation and to the disturbance of nucleoside utilization in reactions of the pentose phosphate pathway. It is supposed that the inhibition of the phosphoribomutase reaction by phosphate is important for regulation of nucleoside and nucleotide formation in a cell.
研究了不同磷酸盐浓度对大鼠肝脏匀浆中腺苷降解的影响。结果表明，磷酸盐显著抑制磷酸核糖变位酶反应，而对腺苷脱氨酶和嘌呤核苷磷酸化酶活性无显著影响，这导致1-磷酸核糖积累，并扰乱戊糖磷酸途径反应中的核苷利用。据推测，磷酸盐对磷酸核糖变位酶反应的抑制作用对于细胞内核苷和核苷酸形成的调节很重要。
