Stott E J, Thomas L H, Howard C J, Gourlay R N
Agricultural and Food Research Council Institute for Animal Disease Research, Compton Laboratory, Berkshire.
Vet Rec. 1987 Oct 10;121(15):342-7. doi: 10.1136/vr.121.15.342.
A quadrivalent vaccine containing the killed antigens of respiratory syncytial virus, parainfluenza virus type 3, Mycoplasma dispar and M bovis, emulsified with an oil adjuvant, was tested for efficacy against naturally occurring calf respiratory disease. Three batches of beef cattle aged 12, seven and three weeks at the time of first vaccination were used. Within each batch of approximately 100 animals, half were vaccinated subcutaneously on three occasions, three weeks apart and half served as unvaccinated controls. Over the trial period, from November 1981 to May 1982, 27 per cent of the control calves were treated for respiratory disease compared with 16.3 per cent of the vaccinated animals. This reduction of non-fatal disease in the vaccinated animals represented a protection rate of almost 40 per cent and was statistically significant (P less than 0.05). Mortality was also reduced from 3.4 per cent in the control calves to 1.9 per cent in the vaccinated animals but this difference was not statistically significant. During a major outbreak of disease associated with respiratory syncytial virus, the protection rate increased to 69 per cent (P less than 0.01). Furthermore, in the batch of cattle aged seven weeks at first vaccination there was significantly less pneumonic consolidation at death in the vaccinated animals than in the control animals (P less than 0.05).
一种含有呼吸道合胞病毒、3型副流感病毒、副溶血性支原体和牛支原体灭活抗原，并与油佐剂乳化的四价疫苗，针对自然发生的犊牛呼吸道疾病进行了疗效测试。使用了三批初次接种疫苗时年龄分别为12周、7周和3周的肉牛。在每批约100只动物中，一半动物分三次皮下接种，每次间隔三周，另一半作为未接种疫苗的对照。在1981年11月至1982年5月的试验期内，27%的对照犊牛因呼吸道疾病接受治疗，而接种疫苗的动物为16.3%。接种疫苗动物中非致命疾病的减少代表了近40%的保护率，且具有统计学意义（P小于0.05）。死亡率也从对照犊牛的3.4%降至接种疫苗动物的1.9%，但这种差异无统计学意义。在与呼吸道合胞病毒相关的重大疾病暴发期间，保护率提高到69%（P小于0.01）。此外，在初次接种疫苗时年龄为7周的那批牛中，接种疫苗的动物死亡时肺部实变明显少于对照动物（P小于0.05）。
