α/β干扰素和γ干扰素在体内由非细胞病变性牛病毒性腹泻病毒感染诱导产生。
Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo.
作者信息
Charleston B, Brackenbury L S, Carr B V, Fray M D, Hope J C, Howard C J, Morrison W I
机构信息
Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom.
出版信息
J Virol. 2002 Jan;76(2):923-7. doi: 10.1128/jvi.76.2.923-927.2002.
Abstract
In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor beta (TGF-beta) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-beta.
摘要
与之前的体外研究结果相反，在无菌动物中发现，用非细胞病变性牛病毒性腹泻病毒（ncpBVDV）对犊牛进行实验性感染可诱导强烈的α/β和γ干扰素反应。这些反应与血清中转化生长因子β（TGF-β）水平降低有关。本研究结果表明，ncpBVDV引起的免疫抑制与低干扰素反应或TGF-β水平升高无关。
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