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Noncytopathic bovine viral diarrhea virus inhibits double-stranded RNA-induced apoptosis and interferon synthesis.非致细胞病变性牛病毒性腹泻病毒抑制双链RNA诱导的细胞凋亡和干扰素合成。
J Virol. 2001 May;75(10):4692-8. doi: 10.1128/JVI.75.10.4692-4698.2001.
2
Validation of an Mx/CAT reporter gene assay for the quantification of bovine type-I interferon.用于定量牛I型干扰素的Mx/CAT报告基因检测法的验证
J Immunol Methods. 2001 Mar 1;249(1-2):235-44. doi: 10.1016/s0022-1759(00)00359-8.
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Type I interferons and T helper development.
Immunol Today. 2000 Oct;21(10):484-9. doi: 10.1016/s0167-5699(00)01710-2.
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Dendritic cells induce CD4+ and CD8+ T-cell responses to Mycobacterium bovis and M. avium antigens in Bacille Calmette Guérin vaccinated and nonvaccinated cattle.树突状细胞在卡介苗接种和未接种的牛中诱导针对牛分枝杆菌和鸟分枝杆菌抗原的CD4+和CD8+ T细胞反应。
Scand J Immunol. 2000 Sep;52(3):285-91. doi: 10.1046/j.1365-3083.2000.00780.x.
5
DNA vaccines encoding viral glycoproteins induce nonspecific immunity and Mx protein synthesis in fish.编码病毒糖蛋白的DNA疫苗可诱导鱼类产生非特异性免疫并合成Mx蛋白。
J Virol. 2000 Aug;74(15):7048-54. doi: 10.1128/jvi.74.15.7048-7054.2000.
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CD4(+) T-cell responses to bovine viral diarrhoea virus in cattle.牛体内针对牛病毒性腹泻病毒的CD4(+) T细胞反应。
Virus Res. 2000 Mar;67(1):67-80. doi: 10.1016/s0168-1702(00)00131-3.
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Bovine viral diarrhea virus: its effects on estradiol, progesterone and prostaglandin secretion in the cow.
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Elevated serum transforming growth factor beta1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM.爱泼斯坦-巴尔病毒相关疾病中血清转化生长因子β1水平升高及其与病毒特异性免疫球蛋白A（IgA）和免疫球蛋白M（IgM）的相关性
J Virol. 2000 Mar;74(5):2443-6. doi: 10.1128/jvi.74.5.2443-2446.2000.
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Differential cytokine responses of CD4+ and CD8+ T cells in response to bovine viral diarrhoea virus in cattle.
J Gen Virol. 1999 Jul;80 ( Pt 7):1673-1679. doi: 10.1099/0022-1317-80-7-1673.
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Transforming growth factor beta in infectious disease: always there for the host and the pathogen.传染病中的转化生长因子β：始终作用于宿主和病原体。
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α/β干扰素和γ干扰素在体内由非细胞病变性牛病毒性腹泻病毒感染诱导产生。

Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo.

作者信息

Charleston B, Brackenbury L S, Carr B V, Fray M D, Hope J C, Howard C J, Morrison W I

机构信息

Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom.

出版信息

J Virol. 2002 Jan;76(2):923-7. doi: 10.1128/jvi.76.2.923-927.2002.

DOI:10.1128/jvi.76.2.923-927.2002
PMID:11752182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC136826/
Abstract

In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor beta (TGF-beta) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-beta.

摘要

与之前的体外研究结果相反，在无菌动物中发现，用非细胞病变性牛病毒性腹泻病毒（ncpBVDV）对犊牛进行实验性感染可诱导强烈的α/β和γ干扰素反应。这些反应与血清中转化生长因子β（TGF-β）水平降低有关。本研究结果表明，ncpBVDV引起的免疫抑制与低干扰素反应或TGF-β水平升高无关。