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[几种新型胃分泌抑制剂]

[Several new inhibitors of gastric secretion].

作者信息

Vasilevskaia L S

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1978 Jun;64(6):871-5.

PMID:28254
Abstract

In experiments on dogs, milid (proglymid) entailed a weak inhibition of the 2nd phase of the gastric secretion leaving intact the 1st phase. The action of LS-519 was obvious in the 1st phase, having entailed a significant inhibition. The glycomacropeptid exerted a strong inhibiting effect both on the 1st and the 2nd phases, the effect lasting longer than that of the first two drugs. All the three drugs not only inhibited the gastric secretion but increased pH, reduced the gastric juice acidity while exerting no significan effect on concentration of common proteinases.

摘要

在对狗的实验中,米立德(丙谷胺)对胃分泌的第二阶段有微弱抑制作用,而第一阶段不受影响。LS - 519在第一阶段作用明显,产生了显著抑制作用。糖巨肽对第一阶段和第二阶段均有强烈抑制作用,且作用持续时间比前两种药物更长。这三种药物不仅抑制胃分泌,还能提高pH值,降低胃液酸度,同时对普通蛋白酶的浓度没有显著影响。

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