Chernikov M P, Stan E Ia, Vasilevskaia L S, Shlygin G K
Vopr Pitan. 1979 Sep-Oct(5):22-6.
A number of fractions with differing intensity of the inhibitory action on the gastric secretion were obtained by gel filtration in a column with biogels P-30 and P-2 of cappa-casein glycomacropeptide. A low-molecular fraction displays the greatest capacity for inhibiting gastric secretion. Desialism, heating and partial hydrolysis of glycomacropeptide with pepsin, trypsin and chemotrypsin used separately have no effect on its inhibitory activity. The resulting data suggest that the inhibitory action of glycomacropeptide is caused by a certain part rather than by entire molecule.
通过在装有生物凝胶P - 30和P - 2的柱中对κ-酪蛋白糖巨肽进行凝胶过滤，得到了对胃液分泌具有不同抑制作用强度的多个级分。低分子级分显示出最大的抑制胃液分泌的能力。分别用胃蛋白酶、胰蛋白酶和糜蛋白酶对糖巨肽进行去唾液酸、加热和部分水解，对其抑制活性没有影响。所得数据表明，糖巨肽的抑制作用是由特定部分而非整个分子引起的。
