Xie Yawei, Chen Lujun, Liu Rui
School of Environment, Tsinghua University, Beijing 100084, China.
School of Environment, Tsinghua University, Beijing 100084, China; Zhejiang Provincial Key Laboratory of Water Science and Technology, Zhejiang 314006, China.
J Environ Sci (China). 2017 Feb;52:170-177. doi: 10.1016/j.jes.2016.04.014. Epub 2016 May 16.
Adsorbable organic halogens (AOX) are a general indicator for the total amount of compounds containing organically bonded halogens. AOX concentrations and components were investigated along the wastewater treatment process in four large-scale pharmaceutical factories of China, and genotoxicity based on the SOS/umu test was also evaluated. The results showed that AOX concentrations in wastewater of four factories ranged from 4.6 to 619.4mg/L, which were high but greatly different owing to differences in the raw materials and products. The wastewater treatment process removed 50.0%-89.9% of AOX, leaving 1.3-302.5mg/L AOX in the effluents. Genotoxicity levels ranged between 2.1 and 68.0μg 4-NQO/L in the raw wastewater and decreased to 1.2-41.2μg 4-NQO/L in the effluents of the wastewater treatment plants (WWTPs). One of the main products of factory I, ciprofloxacin, was identified as the predominant contributor to its genotoxicity. However, for the other three factories, no significant relationship was observed between genotoxicity and detected AOX compounds.
可吸附有机卤素（AOX）是含有机键合卤素化合物总量的一个通用指标。对中国四家大型制药厂废水处理过程中的AOX浓度及成分进行了研究，并基于SOS/umu试验对其遗传毒性进行了评估。结果表明，四家工厂废水中的AOX浓度在4.6至619.4mg/L之间，浓度较高，但由于原材料和产品不同而差异很大。废水处理过程去除了50.0%-89.9%的AOX，最终出水的AOX浓度为1.3-302.5mg/L。原废水中的遗传毒性水平在2.1至68.0μg 4-NQO/L之间，在污水处理厂（WWTPs）出水中降至1.2-41.2μg 4-NQO/L。工厂I的主要产品之一环丙沙星被确定为其遗传毒性的主要贡献者。然而，对于其他三家工厂，未观察到遗传毒性与检测到的AOX化合物之间存在显著关系。
