Zhang Rong-Qiang, Li Hong-Bing, Li Feng-Ying, Han Li-Xin, Xiong Yong-Min
School of Public Health, Shaanxi University of Chinese Medicine, Shiji Road, Xianyang, Shaanxi 712046, PR China; Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education; Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, Xi'an, Shaanxi 710061, PR China.
Center for Disease Control and Prevention of Baoji City, Shaanxi 721006, PR China.
J Infect Public Health. 2017 Sep-Oct;10(5):624-629. doi: 10.1016/j.jiph.2017.02.005. Epub 2017 Feb 21.
This study was a cross-sectional case-control study aimed at (1) identifying risk factors contributing to the measles epidemic and (2) evaluating the impacts of measles-containing vaccines (MCVs), with the goal of providing evidence-based recommendations for measles elimination strategies in China. Data on measles cases from 2000 to 2014 were obtained from a passive surveillance system at the Center for Diseases Prevention and Control in Xianyang. The effectiveness of MCVs was evaluated in 357 patients with a vaccination history and 503 healthy randomly selected controls. Patient data were subjected to multivariable logistic regression modeling. From 2005 to 2014, the average incidence of measles in Xianyang was 5.42 cases per 100,000 people. The second MCV dose was highly protective in 8-month-old infants. MCVs in general have been highly protective in 8-month-old infants. Multivariable logistic regression modeling indicated that age (≥2 years vs. <2years), MCV dose 2 vaccination, and MV vaccination were each independently associated with measles case status. In conclusions: A MCV should be administered on time to all age-eligible children, reproductive-age women, and migrant populations, to maximize herd immunity to measles.
本研究为一项横断面病例对照研究，旨在：（1）确定导致麻疹流行的危险因素；（2）评估含麻疹疫苗（MCV）的影响，目标是为中国消除麻疹策略提供循证建议。2000年至2014年麻疹病例数据来自咸阳市疾病预防控制中心的被动监测系统。在357例有疫苗接种史的患者和503例随机选取的健康对照中评估了MCV的有效性。对患者数据进行多变量逻辑回归建模。2005年至2014年，咸阳市麻疹平均发病率为每10万人5.42例。第二剂MCV对8月龄婴儿具有高度保护作用。总体而言，MCV对8月龄婴儿具有高度保护作用。多变量逻辑回归建模表明，年龄（≥2岁与＜2岁）、第二剂MCV接种以及麻疹疫苗接种均各自独立与麻疹病例状态相关。结论：应及时为所有符合年龄的儿童、育龄妇女和流动人口接种MCV，以最大限度提高人群对麻疹的免疫力。
