Wang Xiaoqin, Ma Mei, Hui Zhaozhao, Terry Paul D, Zhang Yue, Su Rui, Wang Mingxu, Gu Wei, Li Ling
Department of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Department of Medicine, University of Tennessee Medical Center, Knoxville, TN 37920, USA.
Int J Environ Res Public Health. 2017 Jun 6;14(6):605. doi: 10.3390/ijerph14060605.
: Supplementary measles immunization has been implemented since 2010 throughout China, yet few studies have reported its effect in the northwest regions. A cross-sectional study was conducted among children aged 2 to 4 years old ( = 755) from February to September 2014 in 25 towns of Qian County, Shaanxi Province. Blood samples were analyzed for measles antibodies using enzyme-linked immunosorbent immunoglobulin G (IgG) assays. Socio-demographic factors were assessed by questionnaire. Data on vaccine dose were collected from town medical records. Univariate and logistic regression analyses were used to determine factors associated with measles antibody seropositivity. : Measles antibody seroprevalence was 91.13% (95% CI: 89.52-92.83) in our sample. Compared with children whose mother's highest education was primary school, seroprevalence was higher in children whose maternal education was middle school (adjusted OR: 1.4, 95% CI: 0.7-2.8), high school (adjusted OR: 2.4, 95% CI: 1.3-7.7), and college/university (adjusted OR: 2.9, 95% CI: 1.2-9.3). Vaccine dose was positively associated with seropositivity. : Measles seroprevalence is high in China and is associated with the mother's education and vaccine dose.
自2010年起，中国已在全国范围内实施麻疹补充免疫，但很少有研究报道其在西北地区的效果。2014年2月至9月，在陕西省乾县的25个乡镇对755名2至4岁儿童进行了一项横断面研究。采用酶联免疫吸附免疫球蛋白G（IgG）检测法对血样进行麻疹抗体分析。通过问卷调查评估社会人口学因素。从乡镇医疗记录中收集疫苗接种剂量数据。采用单因素分析和逻辑回归分析来确定与麻疹抗体血清阳性相关的因素。结果显示：我们样本中的麻疹抗体血清阳性率为91.13%（95%可信区间：89.52 - 92.83）。与母亲最高学历为小学的儿童相比，母亲学历为初中（调整后比值比：1.4，95%可信区间：0.7 - 2.8）、高中（调整后比值比：2.4，95%可信区间：1.3 - 7.7）和大专/本科（调整后比值比：2.9，95%可信区间：1.2 - 9.3）的儿童血清阳性率更高。疫苗接种剂量与血清阳性呈正相关。结论：中国麻疹血清阳性率较高，且与母亲的教育程度和疫苗接种剂量有关。
