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南部社区队列研究中的心力衰竭发病率和死亡率

Heart Failure Incidence and Mortality in the Southern Community Cohort Study.

作者信息

Akwo Elvis A, Kabagambe Edmond K, Wang Thomas J, Harrell Frank E, Blot William J, Mumma Michael, Gupta Deepak K, Lipworth Loren

机构信息

From the Division of Epidemiology (E.A.A., E.K.K., W.J.B., L.L.), Division of Cardiovascular Medicine (T.J.W., D.K.G.), and Vanderbilt Translational and Clinical Cardiovascular Research Center (V-TRACC) (E.A.A., E.K.K., T.J.W., F.E.H., D.K.G., L.L.), Department of Medicine, and Department of Biostatistics (F.E.H.), Vanderbilt University School of Medicine, Nashville, TN; and Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN (M.M.).

出版信息

Circ Heart Fail. 2017 Mar;10(3). doi: 10.1161/CIRCHEARTFAILURE.116.003553.

Abstract

BACKGROUND

There is a paucity of data on heart failure (HF) incidence among low-income and minority populations. Our objective was to investigate HF incidence and post-HF survival by race and sex among low-income adults in the southeastern United States.

METHODS AND RESULTS

Participants were 27 078 white and black men and women enrolled during 2002 to 2009 in the SCCS (Southern Community Cohort Study) who had no history of HF and were receiving Centers for Medicare and Medicaid Services. Incident HF diagnoses through December 31, 2010 were ascertained using 9th Revision codes 428.x via linkage with Centers for Medicare and Medicaid Services research files. Most participants were black (68.8%), women (62.6%), and earned <$15 000/y (69.7%); mean age was 55.5 (10.4) years. Risk factors for HF were common: hypertension (62.5%), diabetes mellitus (26.5%), myocardial infarction (8.6%), and obesity (44.8%). Over a median follow-up of 5.2 years, 4341 participants were diagnosed with HF. The age-standardized incidence rates were 34.8, 37.3, 34.9, and 35.6 /1000 person-years in white women, white men, black men, and black women, respectively, remarkably higher than previously reported. Among HF cases, 952 deaths occurred over a median follow-up of 2.3 years. Men had lower survival; hazard ratios and 95% confidence intervals were 1.63 (1.27-2.08), 1.38 (1.11-1.72), and 0.90 (0.73-1.12) for white men, black men, and black women compared with white women.

CONCLUSIONS

In this low-income population, HF incidence was higher for all race-sex groups than previously reported in other cohorts. The SCCS is a unique resource to investigate determinants of HF risk in a segment of the population underrepresented in other existing cohorts.

摘要

背景

关于低收入和少数族裔人群中心力衰竭(HF)发病率的数据匮乏。我们的目标是调查美国东南部低收入成年人中按种族和性别划分的HF发病率及HF后的生存率。

方法与结果

参与者为2002年至2009年期间纳入南方社区队列研究(SCCS)的27078名白人和黑人男性及女性,他们无HF病史且正在接受医疗保险和医疗补助服务中心的服务。通过与医疗保险和医疗补助服务中心研究文件链接,使用国际疾病分类第9版代码428.x确定截至2010年12月31日的HF确诊病例。大多数参与者为黑人(68.8%)、女性(62.6%)且年收入低于15000美元(69.7%);平均年龄为55.5(10.4)岁。HF的危险因素很常见:高血压(62.5%)、糖尿病(26.5%)、心肌梗死(8.6%)和肥胖(44.8%)。在中位随访5.2年期间,4341名参与者被诊断为HF。白人女性、白人男性、黑人男性和黑人女性的年龄标准化发病率分别为34.8、37.3、34.9和35.6/1000人年,显著高于先前报道。在HF病例中,在中位随访2.3年期间有952人死亡。男性的生存率较低;与白人女性相比,白人男性、黑人男性和黑人女性的风险比及95%置信区间分别为1.63(1.27 - 2.08)、1.38(1.11 - 1.72)和0.90(0.73 - 1.12)。

结论

在这一低收入人群中,所有种族 - 性别组的HF发病率均高于其他队列先前报道的水平。SCCS是调查在其他现有队列中代表性不足的一部分人群中HF风险决定因素的独特资源。

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