Oberman H A
Department of Pathology, University of Michigan Medical Center, Ann Arbor.
Am J Clin Pathol. 1987 Dec;88(6):718-21. doi: 10.1093/ajcp/88.6.718.
Three patients are described who had invasive ductal carcinoma associated with noncaseating epithelioid granulomas. Multinucleated giant cells, predominantly of Langhans' type, were present in the granulomas. The granulomas were restricted to the carcinoma, and no granulomatous response was evident in regional lymph nodes. None of the patients had clinical evidence of systemic granulomatous disease, although one patient subsequently was found to have hepatic portal granulomas. This uncommon tissue response to neoplasm is distinct from carcinomas with osteoclast-like multinucleated giant cells. Similarly, the process differs from the granulomas presenting in axillary lymph nodes that drain a carcinoma.
本文描述了3例患有浸润性导管癌并伴有非干酪样上皮样肉芽肿的患者。肉芽肿中存在多核巨细胞，主要为朗汉斯型。肉芽肿局限于癌组织，区域淋巴结未见明显的肉芽肿反应。尽管1例患者随后被发现有肝门肉芽肿，但所有患者均无全身性肉芽肿病的临床证据。这种对肿瘤罕见的组织反应不同于伴有破骨细胞样多核巨细胞的癌。同样，该过程也不同于引流癌灶的腋窝淋巴结中出现的肉芽肿。
