Alujević A, Jurić G, Separović V, Kruslin B
University Hospital for Tumors, Zagreb, Croatia.
Zentralbl Gynakol. 1997;119(7):343-5.
An unusual case of invasive ductal carcinoma of the breast associated with epitheloid granulomas is reported. Multinucleated giant Langhans'-type giant cells were found in the epitheloid granulomas in breast carcinoma, but there were not present in the breast tissue and axillary lymph nodes. Congo-red deposits were found haphazardly in the stroma between tumor cells and granulomas. Numerous mast cells were found surrounding granulomas. The patient lacked any clinical evidence of the systemic granulomatous disease. The presence of epitheloid granulomas, amyloid deposits and numerous mast cells in invasive breast carcinoma could be related to a host immune response towards the tumor.
本文报道了一例罕见的乳腺浸润性导管癌合并上皮样肉芽肿的病例。在乳腺癌的上皮样肉芽肿中发现了多核朗汉斯型巨细胞，但在乳腺组织和腋窝淋巴结中未发现。刚果红沉积物随机分布于肿瘤细胞和肉芽肿之间的间质中。在肉芽肿周围发现了大量肥大细胞。患者缺乏任何系统性肉芽肿病的临床证据。浸润性乳腺癌中上皮样肉芽肿、淀粉样沉积物和大量肥大细胞的存在可能与宿主对肿瘤的免疫反应有关。
