Nakano T, Fujioka H, Tamura S, Amuro Y, Nabeshima K, Hada T, Higashino K
Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Am J Gastroenterol. 1987 Dec;82(12):1283-6.
The erythrocyte 2,3-diphosphoglycerate (2,3-DPG) was studied in patients with liver diseases, chronic obstructive pulmonary disease, and in normal subjects. The level of 2,3-DPG in liver diseases occurred in the following increasing order: chronic persistent hepatitis, chronic active hepatitis, liver cirrhosis, and cirrhosis with hepatocellular carcinoma. A significant negative correlation between the 2,3-DPG concentration and serum albumin concentration was found in the liver diseases. The 2,3-DPG level was correlated to the serum concentration of total bile acids and to the arterial blood pH. A negative correlation was found between the arterial blood pH and the serum albumin concentration. The level of 2,3-DPG in hepatocellular carcinoma and/or liver cirrhosis was higher than that in more hypoxic chronic obstructive pulmonary disease. And an increased level of 2,3-DPG was also shown in nonhypoxic patients with liver diseases. These results suggest that the level of erythrocyte 2,3-DPG increases according to the severity of the liver disease, and compared to the level in hypoxic chronic obstructive pulmonary disease, the level of erythrocyte 2,3-DPG is higher in both hepatocellular carcinoma and liver cirrhosis.
对患有肝脏疾病、慢性阻塞性肺疾病的患者以及正常受试者的红细胞2,3-二磷酸甘油酸（2,3-DPG）进行了研究。肝脏疾病患者体内2,3-DPG水平按以下递增顺序排列：慢性持续性肝炎、慢性活动性肝炎、肝硬化以及伴有肝细胞癌的肝硬化。在肝脏疾病患者中，发现2,3-DPG浓度与血清白蛋白浓度之间存在显著负相关。2,3-DPG水平与血清总胆汁酸浓度以及动脉血pH值相关。动脉血pH值与血清白蛋白浓度之间存在负相关。肝细胞癌和/或肝硬化患者的2,3-DPG水平高于缺氧程度更严重的慢性阻塞性肺疾病患者。并且在无缺氧情况的肝脏疾病患者中也显示出2,3-DPG水平升高。这些结果表明，红细胞2,3-DPG水平随肝脏疾病严重程度增加而升高，并且与缺氧的慢性阻塞性肺疾病患者相比，肝细胞癌和肝硬化患者的红细胞2,3-DPG水平更高。
