Stępień Tomasz, Brożyna Mateusz, Kuzdak Krzysztof, Motylewska Ewelina, Komorowski Jan, Stępień Henryk, Ławnicka Hanna
Clinic of Endocrinological and General Surgery, Chair of Endocrinology, Medical University of Lodz, Pabianicka 62, 93-513 Lodz, Poland.
Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Sterlinga 3, 91-425 Lodz, Poland.
Dis Markers. 2017;2017:4962137. doi: 10.1155/2017/4962137. Epub 2017 Jan 31.
. SERPINE2 and secretory leukocyte protease inhibitor (SLPI) are proteins with anticoagulant properties which could promote solid tumor growth. However, their role in the pathogenesis of thyroid cancer has not been determined. . The aim of this study was to assess serum SERPINE2 and SLPI concentrations in a group of 36 patients with papillary thyroid cancer (PTC) and a group of 19 subjects with multinodular nontoxic goiter (MNG). The control group (CG) consisted of 20 healthy volunteers. Blood samples were collected one day before surgery. Serum SERPINE2 and SLPI concentrations were measured using specific ELISA methods. . Significantly higher concentrations of SERPINE2 and SLPI were found in patients with PTC as compared with MNG and controls. Positive correlation was found between SERPINE2 and SLPI concentrations in PTC patients. The levels of SERPINE2 and SLPI did not differ significantly between MNG and healthy controls. . Our results indicate that SERPINE2 and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
丝氨酸蛋白酶抑制剂2（SERPINE2）和分泌型白细胞蛋白酶抑制剂（SLPI）是具有抗凝特性的蛋白质，它们可能促进实体瘤生长。然而，它们在甲状腺癌发病机制中的作用尚未确定。本研究旨在评估36例甲状腺乳头状癌（PTC）患者和19例多结节性非毒性甲状腺肿（MNG）患者血清中SERPINE2和SLPI的浓度。对照组（CG）由20名健康志愿者组成。术前一天采集血样。采用特异性酶联免疫吸附测定（ELISA）方法检测血清中SERPINE2和SLPI的浓度。与MNG患者和对照组相比，PTC患者血清中SERPINE2和SLPI的浓度显著更高。PTC患者血清中SERPINE2和SLPI的浓度呈正相关。MNG患者与健康对照组血清中SERPINE2和SLPI的水平无显著差异。我们的研究结果表明，SERPINE2和SLPI在甲状腺乳头状癌的发生发展中起重要作用，这意味着在甲状腺肿瘤患者的术前诊断中，评估这两种抗凝分子的血清浓度可作为鉴别恶性肿瘤的额外标志物。
