Serbanescu G L, Gruia M I, Bara M, Anghel R M
"Prof. Dr. Al.Trestioreanu" Institute of Oncology, Bucharest, Romania ; "Carol Davila'' University of Medicine and Pharmacy, Bucharest, Romania.
Research Department, "Prof. Dr. Al. Trestiorenu" Institute of Oncology, Bucharest, Romania.
J Med Life. 2017 Jan-Mar;10(1):99-103.
Nowadays, rectal cancer is an important healthcare challenge that affects many thousands of people each year worldwide, being diagnosed especially after the age of 50 years. This study attempted to evaluate the oxidative stress in patients with rectal cancer. 30 patients from the "Prof. Dr. Al. Trestioreanu" Institute of Oncology in Bucharest were treated with neoadjuvant radiochemotherapy during 2014 and 2016 and were included in the clinical study. Blood samples were obtained in dynamics during the treatment. From the blood samples, the serum was separated and used to identify the biochemical oxidative stress parameters. Regarding the determination of lipid peroxides, albumin thiols, the cuprum oxidase activity of ceruloplasmin, the values registered in the dynamic of the treatment highlighted their increase to a maximum at the treatment's endpoint due to an important oxidative stress. Regarding the serum values for total antioxidants, the results pointed out the activation of the natural protection systems, which in time were overwhelmed, due to the installed oxidative stress. Part of the cytotoxic effect of radiotherapy was due to the production of oxidative stress. The cell was constantly exposed to the cytotoxic action of the reactive oxygen species. The obtained results indicated the dual relation to which the tumoral cell exposed itself and the installed oxidative stress, respectively, the oxidative stress being a cause or a consequence of the malign transformation. : CT = computed tomography, MRI = magnetic resonance imaging, ESMO = European Society for Medical Oncology, ECOG = performance status scale.
如今，直肠癌是一项重大的医疗保健挑战，每年在全球影响着成千上万的人，尤其在50岁以后被诊断出来。本研究试图评估直肠癌患者的氧化应激情况。2014年至2016年期间，来自布加勒斯特“阿尔. 特雷肖雷亚努教授”肿瘤研究所的30名患者接受了新辅助放化疗，并被纳入临床研究。在治疗期间动态采集血样。从血样中分离出血清，用于鉴定生化氧化应激参数。关于脂质过氧化物、白蛋白巯基、铜蓝蛋白的铜氧化酶活性的测定，治疗动态过程中记录的值表明，由于重要的氧化应激，它们在治疗终点时增加到最大值。关于总抗氧化剂的血清值，结果指出自然保护系统被激活，但由于所产生的氧化应激，这些系统最终不堪重负。放疗的部分细胞毒性作用归因于氧化应激的产生。细胞不断暴露于活性氧的细胞毒性作用之下。所获得的结果表明肿瘤细胞分别与所产生的氧化应激存在双重关系，氧化应激既是恶性转化的原因，也是其结果。：CT = 计算机断层扫描，MRI = 磁共振成像，ESMO = 欧洲医学肿瘤学会，ECOG = 体能状态量表
