Noorifard M, Sekhavati E, Jalaei Khoo H, Hazraty I, Tabrizi R
Department of Infectious Diseases, AJA University of Medical Sciences, Tehran, Iran.
Larestan School of Medical Sciences, Larestan, Iran.
J Med Life. 2015;8(Spec Iss 2):32-37.
Mucormycosis is an opportunist fungus infection with acute and rapidly progressive nature in the hematologic malignancy patients. This study was done to investigate the prevalence and clinical manifestations of this infection among hematologic malignancies. This cross-sectional study (descriptive-analytical) was performed while investigating medical records of 30 patients with hematologic malignancy affected by Mucormycosis in Imam Reza Hospital between 2001 and 2013. After collecting the data, it was entered in SPSS 19 Software with a provided checklist that included demographic characteristics, clinical manifestations, and it was analyzed by using descriptive (mean, frequency) and inferential (chi- square and independent -t-test) statistical methods (p-value < 0.05 was considered as statistically significant). Overall, the prevalence of Mucormycosis was 4.29 per 100 patient hematologic malignancies. The infection proportion among men and women was 72. 2, 27.6%, respectively. The maximum cases of Mucormycosis were observed among AML patients (62.1%). The most common place of involvement was lung (89.4%) and fever was the most popular sign of the infection (100%). The most considerable and effective factor in the prognosis of infection was using combined therapy of Amphotericin Band surgery (debridement) that has statistically significant correlation (p<0.05). Considerable prevalence and death related to Mucormycosis infection among patients of hematologic malignancy showed the importance of having strategies for its prevention and early diagnosis especially among acute leukemia patients.
毛霉病是血液系统恶性肿瘤患者中一种具有急性和快速进展特性的机会性真菌感染。本研究旨在调查这种感染在血液系统恶性肿瘤中的患病率及临床表现。这项横断面研究（描述性分析）是在调查2001年至2013年期间在伊玛目礼萨医院确诊为毛霉病的30例血液系统恶性肿瘤患者的病历资料时进行的。收集数据后，将其录入SPSS 19软件，并依据包含人口统计学特征、临床表现的既定清单进行分析，采用描述性统计方法（均值、频率）和推断性统计方法（卡方检验和独立样本t检验）（p值<0.05被视为具有统计学意义）。总体而言，毛霉病的患病率为每100例血液系统恶性肿瘤患者中有4.29例。男性和女性的感染比例分别为72.2%和27.6%。毛霉病病例最多见于急性髓系白血病（AML）患者（62.1%）。最常受累部位是肺部（89.4%），发热是最常见的感染体征（100%）。感染预后最显著且有效的因素是使用两性霉素B联合手术（清创）治疗，这具有统计学显著相关性（p<0.05）。血液系统恶性肿瘤患者中毛霉病感染的高患病率及相关死亡表明制定预防和早期诊断策略的重要性，尤其是在急性白血病患者中。
