Liu Lilin, Wu Huiqin, Liang Jianghong, Wu Wenhao, Peng Ye, Zhou Hua, Li Xi
Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, People's Republic of China.
Department of Clinical Laboratory, The Third Hospital of Quzhou, Quzhou, Zhejiang, 321000, People's Republic of China.
Infect Drug Resist. 2022 Aug 6;15:4285-4290. doi: 10.2147/IDR.S376045. eCollection 2022.
Long-term chemotherapy and immunosuppressants in acute myeloid leukaemia (AML) patients can result in a high risk of opportunistic infections. is an opportunistic pathogen that exists in nature, but infection caused by is rare in the clinic. Notably, the sensitivity and detection time of conventional diagnostic tools for this fungus usually falls short of the needs of clinical diagnosis, resulting in treatment failure. Currently, metagenomics next-generation sequencing (mNGS) has played an important role in the detection of pathogens. Here, we report a case of pneumonia in a haematopoietic stem cell transplantation (HSCT) patient, detected by the mNGS method.
急性髓系白血病（AML）患者长期接受化疗和免疫抑制剂治疗会导致发生机会性感染的风险很高。 是一种存在于自然界的机会性病原体，但由 引起的感染在临床上很少见。值得注意的是，针对这种真菌的传统诊断工具的敏感性和检测时间通常达不到临床诊断的需求，从而导致治疗失败。目前，宏基因组学下一代测序（mNGS）在病原体检测中发挥了重要作用。在此，我们报告一例通过mNGS方法检测到的造血干细胞移植（HSCT）患者发生 肺炎的病例。
