Suppr超能文献

造血干细胞移植后急性髓系白血病患者的感染:宏基因组学下一代测序的临床影响

Infection in a Patient with Acute Myeloid Leukaemia After Haematopoietic Stem Cell Transplantation: Clinical Impact of Metagenomics Next-Generation Sequencing.

作者信息

Liu Lilin, Wu Huiqin, Liang Jianghong, Wu Wenhao, Peng Ye, Zhou Hua, Li Xi

机构信息

Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, People's Republic of China.

Department of Clinical Laboratory, The Third Hospital of Quzhou, Quzhou, Zhejiang, 321000, People's Republic of China.

出版信息

Infect Drug Resist. 2022 Aug 6;15:4285-4290. doi: 10.2147/IDR.S376045. eCollection 2022.

Abstract

Long-term chemotherapy and immunosuppressants in acute myeloid leukaemia (AML) patients can result in a high risk of opportunistic infections. is an opportunistic pathogen that exists in nature, but infection caused by is rare in the clinic. Notably, the sensitivity and detection time of conventional diagnostic tools for this fungus usually falls short of the needs of clinical diagnosis, resulting in treatment failure. Currently, metagenomics next-generation sequencing (mNGS) has played an important role in the detection of pathogens. Here, we report a case of pneumonia in a haematopoietic stem cell transplantation (HSCT) patient, detected by the mNGS method.

摘要

急性髓系白血病(AML)患者长期接受化疗和免疫抑制剂治疗会导致发生机会性感染的风险很高。 是一种存在于自然界的机会性病原体,但由 引起的感染在临床上很少见。值得注意的是,针对这种真菌的传统诊断工具的敏感性和检测时间通常达不到临床诊断的需求,从而导致治疗失败。目前,宏基因组学下一代测序(mNGS)在病原体检测中发挥了重要作用。在此,我们报告一例通过mNGS方法检测到的造血干细胞移植(HSCT)患者发生 肺炎的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c452/9364985/174e3110be19/IDR-15-4285-g0001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验