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粪便中未消化的药丸酷似寄生虫感染。

Undigested Pills in Stool Mimicking Parasitic Infection.

作者信息

Mir Fazia, Achakzai Ilyas, Ibdah Jamal A, Tahan Veysel

机构信息

Division of Gastroenterology and Hepatology, University of Missouri, Columbia, 1 Hospital Drive, Columbia, MO 65212, USA.

Department of Internal Medicine, Erie County Medical Center, 1 John James Audubon Pkwy, Buffalo, NY 14228, USA.

出版信息

Case Rep Gastrointest Med. 2017;2017:3718954. doi: 10.1155/2017/3718954. Epub 2017 Jan 31.

DOI:10.1155/2017/3718954
PMID:28255472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5306965/
Abstract

. Orally ingested medications now come in both immediate release and controlled release preparations. Controlled release preparations were developed by pharmaceutical companies to improve compliance and decrease frequency of pill ingestion. . A 67-year-old obese male patient presented to our clinic with focal abdominal pain that had been present 3 inches below umbilicus for the last three years. This pain was not associated with any trauma or recent heavy lifting. Upon presentation, the patient reported that for the last two months he started to notice pearly oval structures in his stool accompanying his chronic abdominal pain. This had coincided with initiation of his nifedipine pills for his hypertension. He reported seeing these undigested pills daily in his stool. . The undigested pills may pose a cause of concern for both patients and physicians alike, as demonstrated in this case report, because they can mimic a parasitic infection. This can result in unnecessary extensive work-up. It is important to review the medication list for extended release formulations and note that the outer shell can be excreted whole in the stool.

摘要

口服药物现在有速释制剂和控释制剂两种。制药公司开发控释制剂是为了提高患者的依从性并减少服药频率。一名67岁的肥胖男性患者因脐下3英寸处的局部腹痛前来我院就诊,该腹痛已持续三年。此疼痛与任何外伤或近期重物搬运无关。就诊时,患者报告称在过去两个月里,他开始注意到慢性腹痛时粪便中有珍珠样椭圆形结构。这与他开始服用硝苯地平治疗高血压的时间相吻合。他报告每天都在粪便中看到这些未消化的药丸。正如本病例报告所示,未消化的药丸可能会引起患者和医生的担忧,因为它们可能会被误认为是寄生虫感染,从而导致不必要的广泛检查。重要的是要查看用药清单中的缓释制剂,并注意其外壳可能会完整地随粪便排出。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fac1/5306965/ad6bfee1c685/CRIGM2017-3718954.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fac1/5306965/288490cb8484/CRIGM2017-3718954.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fac1/5306965/ad6bfee1c685/CRIGM2017-3718954.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fac1/5306965/288490cb8484/CRIGM2017-3718954.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fac1/5306965/ad6bfee1c685/CRIGM2017-3718954.002.jpg

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本文引用的文献

1
Presence of Tablet Remnants of Nevirapine Extended-Release in Stools and Its Impact on Virological Outcome in HIV-1-Infected Patients: A Prospective Cohort Study.粪便中奈韦拉平缓释片残留的存在及其对HIV-1感染患者病毒学结局的影响:一项前瞻性队列研究。
PLoS One. 2015 Oct 14;10(10):e0140574. doi: 10.1371/journal.pone.0140574. eCollection 2015.
2
A review of the gastrointestinal therapeutic system (GITS) formulation and its effectiveness in the delivery of antihypertensive drug treatment (focus on nifedipine GITS).胃肠道治疗系统(GITS)制剂及其在抗高血压药物治疗给药中的有效性综述(聚焦硝苯地平GITS)。
Integr Blood Press Control. 2013 Jun 25;6:79-87. doi: 10.2147/IBPC.S34803. Print 2013.
3
Bezoar formation requiring endoscopic removal after intentional overdose of extended-release nifedipine.
服用缓释硝苯地平过量后形成牛黄,需内镜下取出。
Pharmacotherapy. 2006 Dec;26(12):1802-5. doi: 10.1592/phco.26.12.1802.
4
Enteric-coated pills as a cause of fecal impaction.肠溶丸剂作为粪便嵌塞的一个原因。
Am J Surg. 1950 Jan;79(1):184, illust. doi: 10.1016/0002-9610(50)90210-8.