Tamada S, Ackerman A B
Department of Dermatology, New York University School of Medicine, NY.
Am J Dermatopathol. 1987 Oct;9(5):380-7. doi: 10.1097/00000372-198710000-00003.
Nineteen cases of dermatofibroma associated with monster cells are reported. The term "monster" (an animal with a strange or terrifying shape, one unusually large for its kind) implies a strikingly atypical cell with an extremely large nucleus. Except for monster cells, these 19 lesions had all of the typical histopathological findings of dermatofibroma. The clinical diagnosis for 16 of these lesions was dermatofibroma (or histiocytoma). Three lesions were submitted without any clinical diagnosis. Eighteen of 19 lesions occurred on the extremities. One was on the back. Monster cells are seen in the early, histiocytic stage of dermatofibroma when lipophages and/or siderophages are usually present in large numbers. Only rarely were mitotic figures seen in dermatofibromas with monster cells, and they were neither numerous nor atypical. It is important for histopathologists to distinguish dermatofibroma with monster cells from cutaneous malignant fibrous histiocytoma and radiation sarcoma. The criteria for differentiation concern primarily the architectural pattern of the lesion rather than its cytological features.
报告了19例伴有怪异细胞的皮肤纤维瘤。“怪异”一词（指形状怪异或可怕的动物，同类中异常巨大的个体）意味着一种具有极大细胞核的显著非典型细胞。除怪异细胞外，这19个病变具有皮肤纤维瘤所有典型的组织病理学表现。其中16个病变的临床诊断为皮肤纤维瘤（或组织细胞瘤）。3个病变送检时无任何临床诊断。19个病变中有18个发生在四肢，1个在背部。怪异细胞见于皮肤纤维瘤的早期组织细胞阶段，此时通常有大量的噬脂细胞和/或含铁血黄素巨噬细胞。在伴有怪异细胞的皮肤纤维瘤中，仅罕见有丝分裂象，且数量不多也不非典型。组织病理学家将伴有怪异细胞的皮肤纤维瘤与皮肤恶性纤维组织细胞瘤和放射性肉瘤区分开来很重要。鉴别标准主要涉及病变的结构模式而非其细胞学特征。
