Renkecz Tibor, Horvath Viola
Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellért tér 4, H-1111, Budapest, Hungary.
Methods Mol Biol. 2017;1575:341-352. doi: 10.1007/978-1-4939-6857-2_21.
Molecularly imprinted polymers (MIPs) gained an expansively growing interest in the past few decades. After an initial, explorative period of preparing MIPs exclusively with bulk polymerization, new polymer synthesis routes have been adapted to overcome the drawbacks of the traditional method. Among these the most appealing is precipitation polymerization that results in nano- and microspheres with narrow size distribution and makes the production of MIPs more straightforward. Here, we describe a precipitation polymerization protocol for a common small molecule template, propranolol that is carried out in the conventional way, in dilute monomer solution. Moreover, a modified precipitation polymerization protocol from concentrated monomer solution is presented for a diclofenac imprinted polymer which makes the synthesis even more versatile and circumvents the disadvantages of the dilute solution conditions.
在过去几十年中，分子印迹聚合物（MIPs）受到了广泛关注。在最初仅采用本体聚合法制备MIPs的探索阶段之后，人们采用了新的聚合物合成路线来克服传统方法的缺点。其中最具吸引力的是沉淀聚合，它能产生尺寸分布窄的纳米和微球，使MIPs的生产更加简便。在此，我们描述了一种以普萘洛尔这种常见小分子为模板的沉淀聚合方案，该方案以常规方式在稀单体溶液中进行。此外，还介绍了一种从浓单体溶液出发的改进沉淀聚合方案，用于制备双氯芬酸印迹聚合物，这使得合成更加通用，并避免了稀溶液条件的缺点。
