Liu Jiang, Yan Yanling, Nie Ying, Shapiro Joseph I
Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
Antioxidants (Basel). 2017 Mar 2;6(1):18. doi: 10.3390/antiox6010018.
Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed. Here we present our progress on the Na/K-ATPase signaling mediated sodium reabsorption in renal proximal tubules, from cardiotonic steroids-mediated to reactive oxygen species (ROS)-mediated Na/K-ATPase signaling that contributes to experimental salt sensitivity.
除了血压盐敏感性的遗传调控外，许多因素已被证明可调节肾脏对钠的处理，这有助于长期血压调节，并且已得到广泛综述。在此，我们展示了我们在肾近端小管中钠/钾-ATP酶信号介导的钠重吸收方面的进展，从强心甾类介导的到活性氧（ROS）介导的钠/钾-ATP酶信号，这些信号导致了实验性盐敏感性。
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