文献检索
文档翻译
深度研究
学术资讯

Zotero 插件

邀请有礼
套餐&价格
历史记录

应用&插件

Zotero 插件浏览器插件 Mac 客户端 Windows 客户端微信小程序

定价

高级版会员购买积分包购买API积分包

服务

文献检索文档翻译深度研究 API 文档 MCP 服务

关于我们

关于 Suppr 公司介绍联系我们用户协议隐私条款

关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

Unsaturated Fatty Acids Maintain Cancer Cell Stemness.不饱和脂肪酸维持癌细胞干性。

Cell Stem Cell. 2017 Mar 2;20(3):291-292. doi: 10.1016/j.stem.2017.02.008.

2

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.脂质去饱和是卵巢癌干细胞的一种代谢标志物和治疗靶点。

Cell Stem Cell. 2017 Mar 2;20(3):303-314.e5. doi: 10.1016/j.stem.2016.11.004. Epub 2016 Dec 29.

3

S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53.S100B通过抑制p53介导卵巢癌干细胞样细胞的干性。

Stem Cells. 2017 Feb;35(2):325-336. doi: 10.1002/stem.2472. Epub 2016 Aug 21.

4

Restored in vivo-like membrane lipidomics positively influence in vitro features of cultured mesenchymal stromal/stem cells derived from human placenta.恢复类似体内的膜脂质组学对源自人胎盘的培养间充质基质/干细胞的体外特性产生积极影响。

Stem Cell Res Ther. 2017 Feb 7;8(1):31. doi: 10.1186/s13287-017-0487-4.

5

Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation.棕榈酸（16:0）与ω-6亚油酸和ω-3α-亚麻酸竞争由脂肪酸去饱和酶2（FADS2）介导的Δ6-去饱和作用。

Biochim Biophys Acta. 2016 Feb;1861(2):91-97. doi: 10.1016/j.bbalip.2015.11.007. Epub 2015 Nov 17.

6

FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells.FOXP1在促进卵巢癌细胞的癌症干细胞样特征方面发挥癌基因的作用。

Oncotarget. 2016 Jan 19;7(3):3506-19. doi: 10.18632/oncotarget.6510.

7

Co-culture of ovarian cancer stem-like cells with macrophages induced SKOV3 cells stemness via IL-8/STAT3 signaling.卵巢癌细胞干细胞与巨噬细胞共培养通过 IL-8/STAT3 信号诱导 SKOV3 细胞干性。

Biomed Pharmacother. 2018 Jul;103:262-271. doi: 10.1016/j.biopha.2018.04.022. Epub 2018 Apr 24.

8

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways.胰腺癌干细胞的蛋白质组学分析：脂肪酸合成和甲羟戊酸途径的功能作用

J Proteomics. 2017 Jan 6;150:310-322. doi: 10.1016/j.jprot.2016.10.002. Epub 2016 Oct 13.

9

Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function.结肠腺癌中饱和与不饱和C18脂肪酸比例增加：对冷冻疗法和脂筏功能的影响。

Med Hypotheses. 2005;65(6):1120-3. doi: 10.1016/j.mehy.2005.05.045. Epub 2005 Aug 5.

10

Autophagy maintains the stemness of ovarian cancer stem cells by FOXA2.自噬通过 FOXA2 维持卵巢癌细胞干的干性。

J Exp Clin Cancer Res. 2017 Nov 29;36(1):171. doi: 10.1186/s13046-017-0644-8.

引用本文的文献

1

Low-Protein Diet Supplemented with Amino Acids Can Regulate the Growth Performance, Meat Quality, and Flavor of the Bamei Pigs.补充氨基酸的低蛋白日粮可调控八眉猪的生长性能、肉质和风味。

Foods. 2025 Mar 11;14(6):946. doi: 10.3390/foods14060946.

2

Unraveling the intricate relationship between lipid metabolism and oncogenic signaling pathways.解析脂质代谢与致癌信号通路之间的复杂关系。

Front Cell Dev Biol. 2024 Jun 12;12:1399065. doi: 10.3389/fcell.2024.1399065. eCollection 2024.

3

Chestnut tannin extract modulates growth performance and fatty acid composition in finishing Tan lambs by regulating blood antioxidant capacity, rumen fermentation, and biohydrogenation.栗单宁提取物通过调节血液抗氧化能力、瘤胃发酵和生物氢化来调节育肥滩羊的生长性能和脂肪酸组成。

BMC Vet Res. 2024 Jan 10;20(1):23. doi: 10.1186/s12917-023-03870-3.

4

Metabolic Profiles of Cancer Stem Cells and Normal Stem Cells and Their Therapeutic Significance.肿瘤干细胞和正常干细胞的代谢特征及其治疗意义。

Cells. 2023 Nov 22;12(23):2686. doi: 10.3390/cells12232686.

5

Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance.靶向 ABCA12 调控的神经酰胺稳态抑制乳腺癌干细胞功能和化疗耐药性。

Sci Adv. 2023 Dec;9(48):eadh1891. doi: 10.1126/sciadv.adh1891. Epub 2023 Dec 1.

6

Unveiling the MUFA-Cancer Connection: Insights from Endogenous and Exogenous Perspectives.揭示 MUFA 与癌症的关联：内源性和外源性视角的洞察。

Int J Mol Sci. 2023 Jun 8;24(12):9921. doi: 10.3390/ijms24129921.

7

Stearoyl-CoA Desaturase 1 as a Therapeutic Biomarker: Focusing on Cancer Stem Cells.硬脂酰辅酶 A 去饱和酶 1 作为一种治疗性生物标志物：聚焦于癌症干细胞。

Int J Mol Sci. 2023 May 18;24(10):8951. doi: 10.3390/ijms24108951.

8

Obesity and prostate cancer - microenvironmental roles of adipose tissue.肥胖与前列腺癌——脂肪组织的微环境作用。

Nat Rev Urol. 2023 Oct;20(10):579-596. doi: 10.1038/s41585-023-00764-9. Epub 2023 May 17.

9

Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2.通过靶向脂肪酸去饱和酶1和2，使耐药性急性髓系白血病干细胞对维奈托克+阿扎胞苷重新敏感。

Metabolites. 2023 Mar 24;13(4):467. doi: 10.3390/metabo13040467.

10

Inulin and Chinese Gallotannin Affect Meat Quality and Lipid Metabolism on Hu Sheep.菊粉和五倍子单宁对湖羊肉质和脂质代谢的影响

Animals (Basel). 2022 Dec 31;13(1):160. doi: 10.3390/ani13010160.

本文引用的文献

1

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.脂质去饱和是卵巢癌干细胞的一种代谢标志物和治疗靶点。

Cell Stem Cell. 2017 Mar 2;20(3):303-314.e5. doi: 10.1016/j.stem.2016.11.004. Epub 2016 Dec 29.

2

Stimulated Raman scattering microscopy: an emerging tool for drug discovery.受激拉曼散射显微镜：药物发现的新兴工具。

Chem Soc Rev. 2016 Apr 21;45(8):2075-89. doi: 10.1039/c5cs00693g. Epub 2016 Feb 3.

3

Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease.开发硬脂酰辅酶 A 去饱和酶-1 抑制剂作为人类疾病新型治疗药物的机遇与挑战。

J Med Chem. 2014 Jun 26;57(12):5039-56. doi: 10.1021/jm401516c. Epub 2013 Dec 20.

4

Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.Snail 通过抑制 FBP1 表达为基底样乳腺癌提供代谢优势。

Cancer Cell. 2013 Mar 18;23(3):316-31. doi: 10.1016/j.ccr.2013.01.022. Epub 2013 Feb 28.

5

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.脂肪细胞促进卵巢癌转移，并为肿瘤的快速生长提供能量。

Nat Med. 2011 Oct 30;17(11):1498-503. doi: 10.1038/nm.2492.

6

Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells.硬脂酰辅酶A去饱和酶参与调控人类转化细胞的增殖、不依赖贴壁生长及存活。

J Biol Chem. 2005 Jul 8;280(27):25339-49. doi: 10.1074/jbc.M501159200. Epub 2005 Apr 25.

7

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.脂肪酸结合蛋白aP2可协调巨噬细胞胆固醇转运和炎症活性。巨噬细胞中aP2的表达会影响过氧化物酶体增殖物激活受体γ和IκB激酶的活性。

J Biol Chem. 2005 Apr 1;280(13):12888-95. doi: 10.1074/jbc.M413788200. Epub 2005 Jan 31.

8

Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.血小板衍生生长因子通过激活磷脂酰肌醇3激酶和固醇调节元件结合蛋白来刺激膜脂合成。

J Biol Chem. 2004 Aug 20;279(34):35392-402. doi: 10.1074/jbc.M405924200. Epub 2004 Jun 22.

9

Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid.小鼠中硬脂酰辅酶A去饱和酶1基因的靶向破坏会导致皮脂腺和睑板腺萎缩以及眼睑中蜡酯的消耗。

J Nutr. 2001 Sep;131(9):2260-8. doi: 10.1093/jn/131.9.2260.

10

Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden.血清磷脂中的脂肪酸组成与乳腺癌风险：瑞典的一项病例对照研究

Int J Cancer. 1999 Nov 26;83(5):585-90. doi: 10.1002/(sici)1097-0215(19991126)83:5<585::aid-ijc2>3.0.co;2-z.

不饱和脂肪酸维持癌细胞干性。

Unsaturated Fatty Acids Maintain Cancer Cell Stemness.

作者信息

Mukherjee Abir, Kenny Hilary A, Lengyel Ernst

机构信息

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL 60637, USA.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL 60637, USA.

出版信息

Cell Stem Cell. 2017 Mar 2;20(3):291-292. doi: 10.1016/j.stem.2017.02.008.

DOI:10.1016/j.stem.2017.02.008

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5956908/

Abstract

Investigation of the metabolic regulation of cancer stem cells is an emerging field that offers promising approaches for identifying and targeting recalcitrant stem cell populations. In this issue of Cell Stem Cell, Li et al. (2017) indicate that increased lipid desaturation is essential to stem-like characteristics in ovarian cancer cells.

摘要

对癌症干细胞代谢调控的研究是一个新兴领域，为识别和靶向顽固的干细胞群体提供了有前景的方法。在本期《细胞·干细胞》杂志中，Li等人（2017年）指出，脂质去饱和作用增强对卵巢癌细胞的干细胞样特性至关重要。