不饱和脂肪酸维持癌细胞干性。
Unsaturated Fatty Acids Maintain Cancer Cell Stemness.
作者信息
Mukherjee Abir, Kenny Hilary A, Lengyel Ernst
机构信息
Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL 60637, USA.
Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL 60637, USA.
出版信息
Cell Stem Cell. 2017 Mar 2;20(3):291-292. doi: 10.1016/j.stem.2017.02.008.
Abstract
Investigation of the metabolic regulation of cancer stem cells is an emerging field that offers promising approaches for identifying and targeting recalcitrant stem cell populations. In this issue of Cell Stem Cell, Li et al. (2017) indicate that increased lipid desaturation is essential to stem-like characteristics in ovarian cancer cells.
摘要
对癌症干细胞代谢调控的研究是一个新兴领域，为识别和靶向顽固的干细胞群体提供了有前景的方法。在本期《细胞·干细胞》杂志中，Li等人（2017年）指出，脂质去饱和作用增强对卵巢癌细胞的干细胞样特性至关重要。
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本文引用的文献
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Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.脂质去饱和是卵巢癌干细胞的一种代谢标志物和治疗靶点。
Cell Stem Cell. 2017 Mar 2;20(3):303-314.e5. doi: 10.1016/j.stem.2016.11.004. Epub 2016 Dec 29.
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Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease.开发硬脂酰辅酶 A 去饱和酶-1 抑制剂作为人类疾病新型治疗药物的机遇与挑战。
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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.脂肪细胞促进卵巢癌转移，并为肿瘤的快速生长提供能量。
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Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells.硬脂酰辅酶A去饱和酶参与调控人类转化细胞的增殖、不依赖贴壁生长及存活。
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Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.血小板衍生生长因子通过激活磷脂酰肌醇3激酶和固醇调节元件结合蛋白来刺激膜脂合成。
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Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid.小鼠中硬脂酰辅酶A去饱和酶1基因的靶向破坏会导致皮脂腺和睑板腺萎缩以及眼睑中蜡酯的消耗。
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