First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Section of Hematology and Medical Oncology, Department of Clinical Therapeutics, General Hospital Alexandra, 11528 Athens, Greece.
Cells. 2023 Nov 22;12(23):2686. doi: 10.3390/cells12232686.
Cancer stem cells (CSCs) are a rare cancer cell population, responsible for the facilitation, progression, and resistance of tumors to therapeutic interventions. This subset of cancer cells with stemness and tumorigenic properties is organized in niches within the tumor microenvironment (TME) and presents altered regulation in a variety of metabolic pathways, including glycolysis, oxidative phosphorylation (OXPHOS), as well as lipid, amino acid, and iron metabolism. CSCs exhibit similarities as well as differences when comparedto normal stem cells, but also possess the ability of metabolic plasticity. In this review, we summarize the metabolic characteristics of normal, non-cancerous stem cells and CSCs. We also highlight the significance and implications of interventions targeting CSC metabolism to potentially achieve more robust clinical responses in the future.
癌症干细胞（CSCs）是一种罕见的癌细胞群体，负责促进、进展和抵抗肿瘤对治疗干预的反应。这种具有干性和致瘤性的癌细胞亚群在肿瘤微环境（TME）的龛位中组织起来，并在各种代谢途径中呈现出改变的调节，包括糖酵解、氧化磷酸化（OXPHOS）以及脂质、氨基酸和铁代谢。CSC 与正常干细胞相比既有相似之处也有不同之处，但也具有代谢可塑性。在这篇综述中，我们总结了正常非癌细胞干细胞和 CSC 的代谢特征。我们还强调了针对 CSC 代谢进行干预的意义和影响，以期在未来获得更强大的临床反应。
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