Caradu Caroline, Bérard Xavier, Midy Dominique, Ducasse Eric
Unit of Vascular Surgery, Université de Bordeaux, CHU de Bordeaux, Bordeaux, France.
Unit of Vascular Surgery, Université de Bordeaux, CHU de Bordeaux, Bordeaux, France.
Ann Vasc Surg. 2017 Aug;43:104-114. doi: 10.1016/j.avsg.2017.01.002. Epub 2017 Feb 28.
The lack of widespread availability of Fenestrated endovascular aneurysm repair (F-EVAR) encouraged alternative strategies. Hence, Chimney graft (CG)-EVAR spread when costs, manufacturing delays, or anatomy preclude F-EVAR. Our objective is to evaluate CG- and F-EVAR outcomes depending on the angulation of target renal arteries and hostility of iliac accesses in order to determine the potential impact of a choice made between both techniques on the basis of preoperative anatomic criteria.
Consecutive patients treated by CG-EVAR or F-EVAR, from January 2010 to January 2015, were considered for inclusion. Anatomic parameters were defined by preoperative computed tomography angiography. A subgroup analysis was performed depending on renal arteries' angulation (cut-off: -30°) and iliac arteries' hostility (cut-off: diameter <6 mm, tortuosity index = 3).
Twenty-six patients were included the CG group (mean age 74.7 ± 6.9 years, 30 target vessels) and 66 in the F-EVAR group (71.7 ± 7.9 years, 133 target vessels). Infrarenal aortic neck length was significantly longer for CG-EVAR (3.3 ± 3.7 vs. 1.8 ± 3.2 mm, P = 0.04), while the distance between the superior mesenteric artery and highest renal artery was shorter in the CG group (11.7 ± 6.2 mm vs. 14.1 ± 5.9 mm, P = 0.06). Longitudinal angulation of the right renal artery was not statistically different between both groups, while the left renal artery presented with a significantly more downward angulation in the CG group (-32.0 ± 15.3 vs. -19.0 ± 19.6, P = 0.003). There were significantly more grade 3 iliac tortuosity indexes for CG-EVAR (P = 0.03) with significantly smaller external iliac diameters (7.8 ± 1.7 vs. 8.8 ± 1.6 mm, P = 0.0009). There was 1 renal artery early occlusion in the <-30° CG subgroup and 2 in the <-30° F-EVAR subgroup where severe downward angulation crushed the stents, with a tendency toward higher early occlusions compared with the ≥-30° F-EVAR subgroup (P = 0.054). Mean follow-up duration was 20 months in the CG group and 14 in the F-EVAR group. Kaplan-Meier estimates showed no significant difference in terms of overall survival, freedom from reintervention, freedom from type I or III endoleak, or patency. In the CG group, 14 patients (53.8%) presented with hostile iliac accesses without any significant difference in terms of limb events.
CG-EVAR is a complementary strategy to F-EVAR, and understanding which technique is applicable to which patient is important to improve outcomes. Our results suggest that considering renal artery angulation and diameter, iliac artery hostility, and aortic neck length among other parameters may help the surgeon make a decision toward the endovascular strategy that seems best suited for each specific patient.
开窗型血管内动脉瘤修复术(F-EVAR)缺乏广泛应用,促使人们采用替代策略。因此,当成本、制造延迟或解剖结构不适合F-EVAR时,烟囱式移植物(CG)-EVAR得以推广。我们的目的是根据目标肾动脉的角度和髂动脉入路的难易程度评估CG-EVAR和F-EVAR的疗效,以便确定根据术前解剖学标准在这两种技术之间做出选择可能产生的影响。
纳入2010年1月至2015年1月期间接受CG-EVAR或F-EVAR治疗的连续患者。术前通过计算机断层扫描血管造影确定解剖参数。根据肾动脉角度(临界值:-30°)和髂动脉入路的难易程度(临界值:直径<6 mm,迂曲指数=3)进行亚组分析。
CG组纳入26例患者(平均年龄74.7±6.9岁,30条目标血管),F-EVAR组纳入66例患者(71.7±7.9岁,133条目标血管)。CG-EVAR的肾下主动脉颈部长度显著更长(3.3±3.7 vs. 1.8±3.2 mm,P=0.04),而CG组中肠系膜上动脉与最高肾动脉之间的距离较短(11.7±6.2 mm vs. 14.1±5.9 mm,P=0.06)。两组右肾动脉的纵向角度无统计学差异,而CG组左肾动脉的向下角度明显更大(-32.0±15.3 vs. -19.0±19.6,P=0.003)。CG-EVAR的髂动脉迂曲指数3级明显更多(P=0.03),髂外动脉直径明显更小(7.8±1.7 vs. 8.8±1.6 mm,P=0.0009)。在< -30°的CG亚组中有1例肾动脉早期闭塞,在< -30°的F-EVAR亚组中有2例,严重的向下角度挤压了支架,与≥ -30°的F-EVAR亚组相比,早期闭塞有增加趋势(P=0.054)。CG组的平均随访时间为20个月,F-EVAR组为14个月。Kaplan-Meier估计显示,在总生存率、免于再次干预、免于I型或III型内漏或通畅率方面无显著差异。在CG组中,14例患者(53.8%)存在髂动脉入路困难,肢体事件方面无显著差异。
CG-EVAR是F-EVAR的补充策略,了解哪种技术适用于哪种患者对于改善治疗效果很重要。我们的结果表明,考虑肾动脉角度和直径、髂动脉入路的难易程度以及主动脉颈部长度等参数可能有助于外科医生决定最适合每个特定患者的血管内治疗策略。