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溴隐亭对大鼠某些内分泌腺及肝脏环磷酸鸟苷含量的影响。

Effects of bromocriptine on cyclic-GMP contents of some endocrine glands and liver in rats.

作者信息

Abu-Jayyab A, el-Denshary E E, el-Hakim M M

机构信息

Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

出版信息

Biosci Rep. 1987 Jul;7(7):559-62. doi: 10.1007/BF01119772.

DOI:10.1007/BF01119772
PMID:2825825
Abstract

Cyclic GMP contents of the thyroid gland and ovary were significantly increased in response to single and multiple treatments of bromocriptine, an effect which was antagonized by sulpiride. Liver and adrenocortical cyclic GMP levels have not been changed by bromocriptine although sulpiride alone induced a significant reduction. The data may indicate the presence of D2 receptors in ovary and thyroid gland that are related to cyclic GMP.

摘要

单次及多次给予溴隐亭后,甲状腺和卵巢中的环磷酸鸟苷(cGMP)含量显著增加,而舒必利可拮抗这一作用。溴隐亭未改变肝脏和肾上腺皮质的环磷酸鸟苷水平,尽管单独使用舒必利可使其显著降低。这些数据可能表明卵巢和甲状腺中存在与环磷酸鸟苷相关的D2受体。

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