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环磷酸腺苷在大鼠某些内分泌腺多巴胺能D2受体作用中的角色。

Role of cyclic AMP in the action of dopaminergic D2 receptors of some endocrine glands in rats.

作者信息

Abu-Jayyab A, el-Denshary E E, Ageel A M, Dakkak M R

机构信息

College of Pharmacy, Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia.

出版信息

Biosci Rep. 1987 Oct;7(10):751-5. doi: 10.1007/BF01116746.

DOI:10.1007/BF01116746
PMID:2833951
Abstract

Short-term and long-term effects of bromocriptine mesylate (10 mg/kg i.p.) on cyclic AMP contents of the liver and some endocrine glands have been investigated in the presence and absence of sulpiride (10 mg/kg i.p.). Results revealed that bromocriptine caused significant elevations in the cyclic AMP contents of the liver and reduction in its adrenocortical content. Bromocriptine effect on the adrenal cortex was antagonized by sulpiride, whereas its effect on the liver was not changed. Bromocriptine did not change the cyclic AMP content in the thyroid gland or the ovary.

摘要

在有和没有舒必利(腹腔注射10mg/kg)的情况下,研究了甲磺酸溴隐亭(腹腔注射10mg/kg)对肝脏和一些内分泌腺中环磷酸腺苷(cAMP)含量的短期和长期影响。结果显示,溴隐亭使肝脏中的cAMP含量显著升高,并使其肾上腺皮质含量降低。舒必利拮抗了溴隐亭对肾上腺皮质的作用,而其对肝脏的作用未改变。溴隐亭未改变甲状腺或卵巢中的cAMP含量。

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Role of cyclic AMP in the action of dopaminergic D2 receptors of some endocrine glands in rats.环磷酸腺苷在大鼠某些内分泌腺多巴胺能D2受体作用中的角色。
Biosci Rep. 1987 Oct;7(10):751-5. doi: 10.1007/BF01116746.
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